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ro 67 7476

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Ro 67-7476
T3478298690-60-5
Ro 67-7476 is a positive allosteric modulator of mGluR1, which can enhance the calcium release induced by glutamate in HEK293 cells expressing rat mGluR1a. The EC50 is 60.1 nM. It is a P-ERK1 2 agonist, and can activate ERK1 2 phosphorylation without the addition of exogenous glutamate (EC50 = 163.3 nM).
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