ras superfamily

(E/Z)-ZINC09659342 is an inhibitor of Lbc-Rho A interaction.

ZCL279 is a small molecule modulator (SMM) that inhibits the interaction between CDC42 and intersectin (ITSN). At lower concentrations (<10 μM), ZCL279 activates Cdc42, a cytoplasmic small GTPase in the Ras superfamily, while at higher concentrations (<10 μM) it significantly inhibits it.

SHY-855 is a pan-RAS inhibitor that effectively blocks the binding of K-Ras protein and other members of the RAS small GTPase superfamily, with an IC50 value ranging from 0.3 to 5 μM. It efficiently inhibits the phosphorylation of downstream targets such as MEK, ERK1/2, and AKT. Additionally, SHY-855 prevents the formation of Ras-GTP active complexes. This compound can be utilized in research related to pancreatic cancer and non-small cell lung cancer.

SHY-867 is a pan-RAS inhibitor that effectively inhibits the binding of K-Ras protein and other members of the RAS small GTPase superfamily, with an IC50 value ranging from 0.5 to 3 μM. It effectively suppresses the phosphorylation of downstream targets such as MEK, ERK1/2, and AKT. Additionally, SHY-867 inhibits the formation of Ras-GTP active complexes and is applicable for research in pancreatic cancer and non-small cell lung cancer.