pyridine-based

Pyridine-4-Acetamide (4-Pyridineacetamide) is a pyridine-based ligand involved in the synthesis of W6S8 clusters.

Tyrosinase-IN-33 (compound 5), a pyridine-based compound, acts as an effective inhibitor of diphenolase activity in mushroom tyrosinase. It significantly reduces enzyme activity with an IC50 of 9.0 μM.

4-Chloropyridine acts as an inhibitor of Nicotinamide N-methyltransferase (NNMT). Serving as a substrate for NNMT, this compound enhances the electrophilicity at the C4 position through methylation of the pyridine nitrogen. This modification facilitates an aromatic nucleophilic substitution reaction with the non-catalytic cysteine (C159) in NNMT, ultimately leading to suicidal activity inhibition of the enzyme. 4-Chloropyridine is a promising candidate for the development of activity-based probes targeting NNMT functions.

N-(4-Bromobutyl)phthalimide plays a crucial role in synthesizing imidazo[4,5-b]pyridine derivatives, as well as calix[4]arene- and thiacalix[4]arene-based oxamate ligands.

Glenvastatin is a HMG-CoA reductase inhibitor which has a pyridine-based structure.

Serine Hydrolase Inhibitor-21 (compound 8), a pyridine-based serine hydrolase inhibitor, exhibits a K i of 429 nM against BuChE, and shows promise for Alzheimer's disease research [1].

GRK5-IN-2, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor. It regulates the expression and or release of insulin and is useful for the metabolic disease research.