pyr3

Pyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).

(Pyr3)-Amyloid β-Protein (3-42) is the predominant amyloid β peptide structure found deposited in the brains of individuals with Alzheimer's disease and Down syndrome. It is thought that (Pyr3)-Amyloid β-Protein (3-42) accumulates in the brain, leading to the formation of insoluble amyloid β-peptide deposits.

(Pyr3)-Amyloid β-Protein (3-42) TFA is a principal amyloid β-peptide structure found in the brains of patients with Alzheimer's disease and Down syndrome. It is believed to accumulate in the brain and initiate the formation of insoluble amyloid β-peptide deposits.