purine riboside

2-Amino-6-O-methyl-2'-O-methyl purine riboside, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include inhibition of DNA synthesis and induction of apoptosis, among others [1].

Purine riboside-5'-O-triphosphate sodium is an active metabolite of Nebularine (HY-103694) and acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM, respectively. It also inhibits calmodulin-dependent protein kinase II (CaMKII), with a Ki value of 590 µM.

Purine riboside triphosphate, a derivative of purine riboside, exhibits structural similarity to adenosine. This naturally occurring base analog possesses inhibitory effects on carcinogenic growth, particularly in cancer ascites cells, by strongly impeding RNA and DNA synthesis.

2,6-Dichloro-2',3',5'-triacetyl-purine riboside is a Halo-nucleoside Nucleoside Derivative, serving as both a scaffold and template.

2-Amino-6-O-methyl-2'-O-methyl purine riboside is a Nucleoside Derivative - 6-Modified purine nucleoside, 2'-Modified nucleoside.

6-Chloropurine riboside (6-CPR) is a purine nucleoside analog that has been found to have a wide range of biological activities. It inhibits the growth of tumor cells and induces apoptosis. It has also been shown to have anti-inflammatory, antiviral and antifungal properties. It has also been found to be neuroprotective and has been used in the treatment of neurological disorders.

2-Chloro-6-(furan-2-yl)purine-beta-D-(3'-deoxy-3'-fluoro)riboside is a nucleoside derivative that is a fluoro-modified nucleoside, 6-modified purine nucleoside, halo-nucleoside, and 3'-modified nucleoside; it serves as a scaffold and template.

6-(Furan-2-yl)purine-beta-D-riboside is a Nucleoside Derivative - 6-Modified purine nucleoside.

6-Chloropurine riboside-5'-triphosphate serves as both an inhibitor and an activator in biochemical processes. It inhibits the RNA triphosphatase mRNA-capping enzyme subunit β (Cet1; IC50 = 2 µM for the GTPase activity of the S. cerevisiae enzyme), proving its efficacy against the enzyme responsible for the capping of mRNA molecules. Additionally, it acts as a phosphorylated derivative of 6-chloropurine riboside. This compound also activates the E. coli enzyme aspartate carbamoyltransferase (EC50 = 0.76 mM), demonstrating its versatility in modulating enzyme activities. It is instrumental in the synthesis of cytokinins with anticancer properties and a photoclickable form of ATP, highlighting its applications in biochemical synthesis and potential therapeutic uses.

Nucleoside Derivatives - Fluoro-modified nucleosides; 6-Modified purine nucleosides, 3'-Modified nucleosides

2',3'-O-Isopropylidene-6-mercaptopurine riboside is a compound with excellent metal complexation activity. It is utilized in the study of mechanisms involving metal complexation.

Nucleoside Derivatives - Halo-nucleosides, 2'-Modified nucleosides; Scaffolds and Templates

Allopurinol riboside is a metabolite of allopurinol with potency against parasites. Allopurinol riboside competitively inhibits the action of purine nucleoside phosphorylase on inosine with a Ki of 277 μM.

5-Methyluridine (Thymine riboside) is an endogenous methylated nucleoside found in human fluids; methylated purine bases are present in higher amounts in tumor-bearing patients compared to healthy controls.DNA hypermethylation is a common finding in malignant cells and has been explored as a therapeutic target for hypomethylating agents.

2-Aminopurine-9-beta-D-(2'-deoxy)riboside, a derivative of 2-Aminopurine, is a modified nucleoside composed of a purine base linked to a (2'-deoxy)ribose sugar moiety.

2,6-Dichloropurine-9-β-D-riboside is a building block.1,2It has been used in the synthesis of photoaffinity probes for nucleotide binding sites in proteins. 1.Wower, J., Hixson, S.S., Sylvers, L.A., et al.Synthesis of 2,6-diazido-9-(β-D-ribofuranosyl)purine 3',5'-bisphosphate: Incorporation into transfer RNA and photochemical labeling of Escherichia coli ribosomesBioconjug. Chem.5(2)158-161(1994) 2.Seiter, M.S., Bauer, M.P., Bogel, P.D., et al.Synthesis of novel spin-labeled photoaffinity derivatives of NAD+ and ATP and their characterization as coenzymes and substrates of several enzymesSynthesis2269-273(1996)

N-6-Furfurylguanosine (kinetin riboside) is a purine nucleoside analog with cytotoxicity. It inhibits cancer cell growth.

Riboxin (IDP), an orally administered purine derivative known as hypoxanthine riboside, exhibits antihypoxic and antihyperthermic effects. Furthermore, it demonstrates antiarrhythmic properties in cats, rabbits, and mice suffering from Ouabain-induced cardiac rhythm abnormalities. Additionally, Riboxin offers protection to animals from the harmful consequences of γ-irradiation [1] [2].

6-Methoxypurine-9-beta-D-(3-methoxy riboside), a purine nucleoside analog, exhibits extensive antitumor effects, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, among others [1].