purine analogue

Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation. Fludarabine has antitumor activity and can be used for the treatment of leukemia and lymphoma.

Adenosine Dialdehyde (Periodate-oxidized adenosine) is a purine nucleoside analogue. Adenosine Dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo.

8-Azaguanine (SK 1150) is a purine analogue with potential antineoplastic activity.

Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A B C(IC50s=150-500 nM).

Azathioprine Sodium is the sodium salt form of azathioprine, a pro-drug of purine analogue with immunosuppressive activity. Azathioprine is converted in vivo to its active metabolite 6-mercaptopurine (6-MP), which substitutes for the normal nucleoside and mistakenly gets incorporated into DNA sequences. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.

CB10-277 is a synthetic derivative of dimethylphenyl-triazene related to dacarbazine, with antineoplastic properties. Related to the agent dacarbazine, CB10-277 is converted in vivo to a monomethyl triazene form that alkylates DNA, resulting in inhibition of DNA replication and repair; in addition, this agent may act as a purine analogue, resulting in inhibition of DNA synthesis, and may interact with protein sulfhydryl groups.

Adenosine-2-carboxy methyl amide, a purine nucleoside analogue, exhibits broad antitumor activity against indolent lymphoid malignancies through mechanisms including DNA synthesis inhibition and apoptosis induction.[1]

N1-Methylsulfonyl pseudouridine, a purine nucleoside analogue, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, among others [1].

N1-(2-Methyl)propyl pseudouridine, a purine nucleoside analogue, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include DNA synthesis inhibition and apoptosis induction, among others [1].

N1-Methoxymethyl pseudouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis , etc [1] .

N1-Benzoyl pseudouridine, a purine nucleoside analogue, exhibits extensive antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, among others [1].

6-Amino-4-methoxy-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine, a purine nucleoside analogue, exhibits widespread antitumor efficacy, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, among others [1].

6-Amino-4-hydrozino-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a purine nucleoside analogue with broad antitumor activity, particularly effective against indolent lymphoid malignancies, working through mechanisms such as inhibiting DNA synthesis and inducing apoptosis, among others [1].

6-Amino-4-hydroxyamino-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine, a purine nucleoside analogue, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include inhibition of DNA synthesis and induction of apoptosis, among others [1].

6-Amino-3-(furan-2-yl)-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a purine nucleoside analogue, exhibits broad antitumor activity by targeting indolent lymphoid malignancies, with its anticancer mechanisms including inhibition of DNA synthesis and induction of apoptosis.

7-Cyclopropyl methyl-7,8-dihydro-8-oxo-9-(β-D-ribofuranosyl)guanine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis , etc [1] .

4-Amino-5-cyano-1-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine, a purine nucleoside analogue, exhibits widespread antitumor efficacy, particularly against indolent lymphoid malignancies. Its anticancer properties primarily stem from the inhibition of DNA synthesis and the induction of apoptosis, among other mechanisms [1].

2'-β-C-Methyl-3-deazauridine, a purine nucleoside analogue, exhibits wide antitumor activity specifically against indolent lymphoid malignancies. Its anticancer mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, among others [1].

(R)-N-(2,3-Dihydro-1H-indenyl)-2-amino adenosine, a purine nucleoside analogue, exhibits broad antitumor activity against indolent lymphoid malignancies by inhibiting DNA synthesis and inducing apoptosis [1].

Uridine-5-oxo-acetyl-(9-fluorenylmethyl) ester, a purine nucleoside analogue, demonstrates broad antitumor activity, particularly against indolent lymphoid malignancies, through mechanisms including inhibition of DNA synthesis and induction of apoptosis [1].

Uridine-5-(N-Fmoc-methylamino)-acetyl (9-fluorenylmethyl) ester, a purine nucleoside analogue, exhibits broad antitumor activity, specifically targeting indolent lymphoid malignancies through mechanisms including the inhibition of DNA synthesis and the induction of apoptosis, among others [1].

3'-Deoxy-3'-fluoroadenosine is a purine nucleoside analogue with broad anti-tumor and anti-viral activity, showing inhibitory effects on tick-borne encephalitis virus (TBEV), Zika virus, and West Nile virus (WNV) with EC50 values of 1.1 μM, 0.1 μM and [4.7 ± 1.5] μM, respectively. It is useful for studying tumor diseases.

5-Hydroxyuridine (OHUrd) is a purine nucleoside analogue with potential antitumor activity, demonstrating cytotoxicity against human colon adenocarcinoma cell lines.

2'-O-Methyl-2-thiouridine is a purine nucleoside analogue present in synthetic thermophilic bacterial tRNAs. 2'-O-Methyl-2-thiouridine is more selective for A than unmodified U.