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By Target- AhR
- Endogenous Metabolite(1)
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potassium 1h-indol-3-yl sulfate
" in TargetMol Product Catalog- Inhibitors & Agonists1
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Potassium 1H-indol-3-yl sulfate
Potassium 3-indoxyl sulfate, Indoxyl sulfate potassium salt
T49382642-37-7
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR), a key regulator of immune-inflammatory conditions. A metabolite of tryptophan derived from dietary protein, it is produced by intestinal bacteria and metabolized in the liver. In chronic kidney disease patients with impaired renal function, it accumulates in serum as a uremic toxin, inducing oxidative stress and accelerating disease progression. At 250 μM, it activates NF-Κb, promoting TGF-β1 and Smad3 expression in rat proximal tubular cells, which is associated with profibrotic activity.
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