pembrolizumab

Pembrolizumab (MK-3475) is a highly selective humanized monoclonal antibody that antagonizes PD-1. It can block the PD-1 protein on T cells and prevent their interaction with PD-L1 on cancer cells.

Quavonlimab (MK-1308) is a novel human monoclonal antibody designed to selectively target and block the immune checkpoint molecule cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), investigation of quavonlimab in combination with the anti-PD-1 therapy KEYTRUDA (pembrolizumab) has shown encouraging anti-tumor activity along with an acceptable safety profile,making it an interesting compound for the reasearches into advanced non-small cell lung cancer (NSCLC).

Favezelimab (MK-4280), a humanized monoclonal antibody directed against LAG-3, inhibits the molecular interaction between LAG-3 and its ligand MHC class II, thereby restoring T-cell function. Favezelimab (MK-4280) has been evaluated as a candidate for colorectal cancer (CRC) research, particularly in studies that investigate synergistic effects in combination with the PD-L1 inhibitor Pembrolizumab (HY-P9902).