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  • Histone Acetyltransferase
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Results for "

pcaf/gcn5

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    14
    TargetMol | Inhibitors_Agonists
  • PROTAC Products
    1
    TargetMol | PROTAC
  • Antibody Products
    1
    TargetMol | Antibody_Products
BRD-IN-3
T106042351938-32-2
BRD-IN-3 is a highly potent PCAF bromodomain (BRD) inhibitor (IC50: 7 nM). It also exhibits activity against GCN5 and FALZ.
  • $2,120
8-10 weeks
Size
QTY
GSK4028
T114952079886-19-2
GSK4028 is the enantiomeric negative control of GSK4027, a PCAF GCN5 bromodomain chemical probe, with a pIC50 of 4.9 in a TR-FRET assay.
  • $1,470
8-10 weeks
Size
QTY
GSK 4027
T11495L2079896-25-4
GSK 4027 is a PCAF GCN5 bromodomain chemical probe. In a time-resolved fluorescence resonance energy transfer (TR-FRET) assay, it has a pIC50 of 7.4±0.11 for PCAF.
  • $268
35 days
Size
QTY
L002
T11807321695-57-2
L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By blocking histone acetylation, p53 acetylation, and STAT3 activation, L002 shows potential in the treatment of hypertension‐induced cardiac hypertrophy and fibrogenesis.
  • $34
In Stock
Size
QTY
TargetMol | Inhibitor Sale
PU139
PU 139, PU-139
T28471158093-65-3
PU139 is a novel inhibitor of histone acetyltransferase (HAT).
  • $48
In Stock
Size
QTY
GSK699
GSK-699, GSK 699
T320102260944-68-9
GSK699 is a potent, cell penetrant PCAF GCN5 PROTAC.
  • $1,700
10-14 weeks
Size
QTY
L Moses dihydrochloride
T36109
High affinity and selective cell-permeable p300/CBP-associated factor (PCAF) inhibitor (Ki = 47 nM). Exhibits no significant activity against a panel of 48 other bromodomains except GCN5 (Kd = 600 nM). Exhibits >4500-fold selectivity for PCAF over BRD4. Also exhibits metabolic stability in mouse and human liver microsomes and no observable cytotoxicity in peripheral blood mononuclear cells (PBMC). Moustakim et al (2017) Discovery of a PCAF bromodomain chemical probe. Angew.Chem.Int.Ed. 56 827 PMID:27966810
  • TBD
35 days
Size
QTY
YF-2 hydrochloride
T387111312005-62-1
YF-2 hydrochloride is a potent histone acetyltransferase activator that exhibits high selectivity and can pass through the blood-brain barrier. It specifically acetylates H3 in the hippocampus, with EC50 values of 2.75 μM, 29.04 μM, and 49.31 μM for CBP, PCAF, and GCN5, respectively. Notably, it does not affect HDAC activity. Moreover, YF-2 hydrochloride demonstrates promising anti-cancer and anti-Alzheimer's disease properties.
    7-10 days
    Inquiry
    YF-2
    T54681311423-89-8
    YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM and 49.31 μM , respectively
    • $50
    In Stock
    Size
    QTY
    F2276-0104
    T71720922128-14-1
    F2276-0104 is a PCAF GCN5 BRD inhibitor
    • $1,520
    6-8 weeks
    Size
    QTY
    F2276-0106
    T71721922054-57-7
    F2276-0106 is a PCAF GCN5 BRD inhibitor
    • $1,520
    6-8 weeks
    Size
    QTY
    F2276-0008
    T71723922000-45-1
    F2276-0008 is a PCAF GCN5 BRD inhibitor.
    • $1,520
    6-8 weeks
    Size
    QTY
    F2276-0099
    T71724921995-90-6
    F2276-0099 is a PCAF GCN5 BRD inhibitor
    • $1,520
    6-8 weeks
    Size
    QTY
    CPTH6 hydrobromide
    T843912321332-57-2
    CPTH6, a thiazole derivative, selectively inhibits the lysine acetyltransferase activity of Gcn5 and pCAF without affecting p300 or CBP. It effectively blocks the acetylation of H3/H4 histones and α-tubulin in various leukemia cell lines, leading to reduced cell viability by arresting the cell cycle in the G0/G1 phase and inducing apoptosis. Additionally, CPTH6 disrupts autophagy across several tumor cell lines, primarily by interfering with ATG7-mediated autophagosomal membrane elongation.
    • $970
    4-6 weeks
    Size
    QTY