pca

PCA50941, a 1,4-dihydropyridine derivative, is used in the treatment of cardiovascular disease.

Methylsilanol PCA is a bioactive chemical.

Pca 4233 belongs to a class of selective PAF-receptor antagonists.

Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with strong antitumor activity.

Trombodipine (PCA-4230) is a platelet aggregation inhibitor with antithrombotic activity and protection against Listeria monocytogenes.

Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine can be used for malaria, systemic lupus erythematosus, and cancer research.

HUHS015 is a potent PCA-1/ALKBH3 inhibitor.

D-Lys(Z)-Pro-Arg-pNA (diacetate) diacetate is a chromogenic substrate.

D-Lys(Z)-Pro-Arg-pNA is a luminescent substrate of activated protein C (APC).

PAF antagonist

Lysine PCA is a bioactive chemical.

Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.

1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH).

HOCPCA is an effective and selective ligand for the GHB binding sites that acts by binding with 27 times better affinity than GHB itself and crossing the blood-brain barrier in vitro and in vivo.

TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases and enzymes.

1,4-DPCA ethyl ester is a form of 1,4-DPCA modified to ethyl ester, which has potential anticancer activity based on growth inhibition assays with the mlh1 rad18 yeast strain.

PCAF-IN-2 (compound 17) is a potent inhibitor of PCAF with an IC50 of 5.31 µM, exhibiting anti-tumor activity by inducing cell apoptosis and arresting the cell cycle at the G2/M phase[1].

PCAF-IN-1 is a highly selective PCAF (p300/CBP-associated factor) inhibitor with potential anti-tumor, anti-inflammatory, and anti-heart disease effects. Inhibition of PCAF attenuates cardiac remodeling after myocardial infarction, reduces polarization of M1-type macrophages, and attenuates autoimmune arthritis.

cPcAMP1/26, an antimicrobial peptide, exhibits potent bactericidal activity against A. hydrophila and S. aureus by inducing depolarization of the bacterial plasma membrane and elevating intracellular ROS (Reactive Oxygen Species) levels [1].

Anti-Mouse CD326/EpCAM Antibody (G8.8) is a rat-derived IgG2a, κ antibody inhibitor targeting mouse CD326/EpCAM.

Anti-CD326/EpCAM Antibody (Ber-EP4) is a mouse IgG1, κ chimeric antibody designed to target human CD326/EpCAM. The recommended isotype control for this antibody is Mouse IgG1 kappa, Isotype Control.

G-Pen-GRGDSPCA TFA is an αvβ3 inhibitory RGD peptide. It inhibits neointimal hyperplasia and luminal narrowing following vascular injury and regulates the migration and proliferation of smooth muscle cells. This compound can be utilized in studies related to mechanisms of vascular injury repair.

SpCas9 D10A Nickase is a variant of the Cas9 protein. This mutation retains the functionality of one cleavage domain of the Cas9 nuclease, allowing it to specifically nick a target single strand. Additionally, SpCas9 D10A Nickase is effective in reducing off-target effects.

Methyl (E)-4-hydroxycinnamatee is found in several plants such as onion or Morinda citrifolia. It induces apoptosis in combination with Carnosic Acid and kills acute myeloid leukemia cells. It has antioxidant and antibacterial activity.