p-q-type ca2+ channel

LY393615 (NCC1048) is a novel blocker of both neuronal Ca²⁺ (calcium) and Na⁺ (sodium) channels, exhibiting half-maximal inhibitory concentrations (IC₅₀) of 1.9 µM and 5.2 µM against α1A and α1B calcium channel subunits, respectively. This compound demonstrates effective brain penetration and has shown neuroprotective effects in cerebral ischemia models, suggesting its utility in neurological disease research [1].

GV-58 is a selective N- and P Q-type Ca2+ channels agonist (EC50: 7.21 8.81 uM for N-type P-Q-type Ca2+ channel). The inhibitory of GV-58 is 20-fold fewer for CDK kinases activity.

ω-Conotoxin MVIIC TFA is a peptide and neurotoxin with 26 residues that preferentially blocks P-type and Q-type Ca ++ currents by binding with high affinity to voltage-sensitive neuronal Ca ++ channels (VGCCs) and can be radiolabeled and used in immunoprecipitation assays.