oxldl binding

BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inte

Anti-CD36 Antibody is a humanized monoclonal antibody targeting CD36 (Fatty Acid Translocase/FAT). CD36 is a multi-ligand scavenger receptor widely expressed on monocytes/macrophages, platelets, endothelial cells, and adipocytes, facilitating the uptake of long-chain fatty acids (LCFA) and the binding of oxidized low-density lipoproteins (oxLDL). By specifically binding to CD36, this antibody blocks fatty acid transport or inhibits oxLDL-induced foam cell formation, making it a valuable tool for research in metabolic disorders (e.g., atherosclerosis, diabetes) and cancer lipid metabolism.