osthole

Osthole (Osthol), a potential inhibitor of histamine H1 receptor, has been shown to stimulate osteoblast proliferation and differentiation.

Osthole (Standard) is a reference standard for research and analysis in studies involving Osthole. Osthole (Osthol), a potential inhibitor of histamine H1 receptor, has been shown to stimulate osteoblast proliferation and differentiation.

2'E-3'-formaldehydylosthole is a natural product that can be used as a reference standard. The CAS number of 2'E-3'-formaldehydylosthole is 73292-92-9.

Micromarin F (E-Methylarnottinin) is a coumarin derivative extracted from the stems of Micromelum minutum Wight et Arn.

AMPK-IN-5 (compound 7m) is a derivative of osthole that inhibits MAPK signaling by blocking the phosphorylation of JNK and p38, thereby suppressing the release of inflammatory cytokines. AMPK-IN-5 can reduce ulcerative colitis induced by dextran sulfate sodium and acute lung injury induced by LPS.

NBM-T-BMX-OS01 is a derivative of Osthole. It can inhibit the phosphorylation of VEGFR2, FAK, Akt, and ERK, demonstrating anti-angiogenic activity. Additionally, NBM-T-BMX-OS01 exhibits anticancer properties against colorectal cancer.

Nrf2 activator-2 (referred to as compound O15), an Osthole derivative, is a highly potent Nrf2 agonist exhibiting an EC 50 of 2.9 μM in 293 T cells. By effectively disrupting the binding between Keap1 and Nrf2, Nrf2 activator-2 activates the Nrf2 pathway. Furthermore, this compound significantly reduces the ubiquitination of Nrf2 in cells, indicating its potential in regulating Nrf2 activity [1].