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By Target By ResearchField- Cardiovascular System(1)
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Results for "
ono 1301
" in TargetMol Product Catalog.- Inhibitors & Agonists2
ONO 1301
ONO-AP 500-02, ONO-1301, ONO1301
T28240176391-41-6
ONO 1301 is a prostaglandin I2 mimetic compound with inhibitory activity against thromboxane A2 synthase, and it suppresses pancreatic fibrosis in the DBTC-induced chronic pancreatitis model by inhibiting monocyte activity through both direct effects of ONO 1301 and induction of hepatocyte growth factor. ONO 1301 also promoting HGF synthesis and elevating intracellular cyclic AMP levels via IP-receptor signaling, highlighting its therapeutic relevance in fibrotic disease and inflammation research.
- $68
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IP receptor antagonist 1
T214186
CAY10449 is an antagonist of the I prostanoid receptor. It is capable of reversing the decrease in transepithelial electrical resistance (TEER) induced by iloprost. Additionally, CAY10449 can counteract the effects of ONO-1301 in mouse models. This compound is useful for research in asthma and allergic airway inflammation.
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