odq

ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.

Solagenin 6-O-β-D-quinovopyranoside is a natural product for research related to life sciences. The catalog number is TN6312 and the CAS number is 184686-03-1.

Neochlorogenin 6-O-β-D-quinovopyranoside is a natural product for research related to life sciences. The catalog number is TN6318 and the CAS number is 711025-86-4.

Digitoxigenin-3-O-β-D-quinovoside, a cardiac lactone extracted from Elaeodendron australe var. integrifolium, serves as an interleukin-2 (IL-2)/luciferase inhibitor, demonstrating an inhibitory concentration (IC 50) of 52 nM.

LOXL2/sGC modulator-1 (Compound 11k) is an LOXL2 inhibitor with an IC₅₀ of 0.13 μM and acts as an sGC activator. It shows good selectivity for LOX (IC₅₀ > 45.9 μM) and LOXL3 (IC₅₀ = 1.30 μM). In the presence of the gGC inhibitor ODQ, it significantly increases intracellular cGMP levels. LOXL2/sGC modulator-1 effectively inhibits hypoxia-induced collagen deposition and cross-linking while promoting vasodilation. This compound is useful for researching pulmonary arterial hypertension.