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Search Results for " nucleus "

Targets

60

Compounds

10

Natural Products

273

Recombinant Proteins

5

Libraries

Cat No. Product Name Synonyms Targets
T9264 ECBN HCL 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]echinocandin B hydrochloride (1:1) Others
ECBN HCL (A-30912A nucleus hydrochloride) is the reaction product catalyzed by Echinocandin B (ECB) deacylase.
T7304 DNQX FG 9041 GluR , iGluR
DNQX (FG 9041) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)
T8459 DNQX disodium salt DNQX Disodium NMDAR , iGluR
DNQX disodium salt is a water-soluble form of selective antagonist of non-NMDA receptor
T4420 4-Hydroxytamoxifen ICI 79280,(Z)-4-hydroxy Tamoxifen,trans-4-Hydroxytamoxifen Estrogen Receptor/ERR , Estrogen/progestogen Receptor
4-Hydroxytamoxifen (ICI 79280) is the active metabolite of Tamoxifen, an estrogen receptor modulator (SERM) with selective and oral potency. 4-Hydroxytamoxifen has antitumor activity and may be used in breast cancer rese...
T11277 FG 7142 ZK 39106,LSU-65 GABA Receptor
FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cereb...
T83651 AC-263093 Neuropeptide Y Receptor
AC-263093 is an NPFFR2 agonist with anxiolytic activity that increases c-Fos protein expression in the paraventricular nucleus of the hypothalamus.
T12220 NIC3 Others
NIC3 is a selective nucleus accumbens-associated protein-1 (NAC1) inhibitor,with anti-cancer activity.
T1844 KPT330,(E)- (E)-RN,KPT-330,KPT330,KPT 330 Others , CRM1
(E)-RN (KPT 330) is a CRM1-selective inhibitor of nuclear export. It inhibits protein trafficking from the nucleus and induces cell cycle arrest and apoptosis in mesothelioma cells.
T23854 Carbidine Carbidine dihydrochloride,Karbidin,Carbidin,Karbidine Others
Carbidine (Carbidin) is a derivative of gamma-carboline, an atypical antipsychotic drug. It reduces the inhibitory effect of DA on the 3H-DA release from synaptosomes of the nucleus accumbens septi and on the activity of...
TP1653L SV40 T-Ag-derived NLS peptide acetate SV40 T-Ag-derived NLS peptide acetate(105425-98-7 free base) Others
SV40 T-Ag-derived NLS peptide acetate (SV40 T-Ag-derived NLS peptide acetate) is a nuclear localization signal peptide. The DNA labeled with this peptide can be effectively transferred to the nucleus.
T2162 Maribavir BW1263W94,GW257406X,Benzimidavir,1263W94 Others , HCV Protease
Maribavir (GW257406X) is an orally available benzimidazole riboside compound with activity against cytomegalovirus (CMV). Maribavir is a selective ATP competitor of the viral UL97 kinase, which is involved in viral nucle...
T1127 Beclometasone dipropionate Beclovent,Beclomethasone dipropionate,Beconase,Vancenase Glucocorticoid Receptor
Beclometasone dipropionate (Vancenase) is the dipropionate ester of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, beclomethasone...
T64317 ZZL-7 Serotonin Transporter
ZZL-7 is a fast-onset antidepressant agent. ZZL-7 disrupts the interaction between the neuronal nitric oxide synthase (nNOS) and serotonin transporter (SERT) in the dorsal raphe nucleus (DRN). ZZL-7 can easily cross the ...
T10904 CWP232228 Wnt/beta-catenin
CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting t...
T16538 PIN1 inhibitor API-1 Others
PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, th...
T1666 Fludrocortisone acetate 9α-Fluorcortisol acetate,9α-Fludrocortisone acetate,9α-fluorocortisol acetate Glucocorticoid Receptor , Autophagy
Fludrocortisone acetate (9α-Fludrocortisone acetate) , a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-respon...
T2548 Diflorasone Glucocorticoid Receptor
Diflorasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorti...
T34963 TSPA
TSPA is an ATF6α translocation inducer which effectively promotes ATF6α translocation into the nucleus and ameliorates glucose homeostasis on db/db mice.
T19055 RT-NH2 Real Thiol-NH2 Others
RT-NH2 is fairly hydrophobic and cannot distribute in the nucleus. It is a RealThiol prototype without the carboxylic acid groups.
T34903 TO-PRO3 iodide TOPRO3 iodide,TO-PRO3 iodide salt
TO-PRO3 iodide is a nucleic acid stain that can stain the nucleus of cells in different states, including living, early apoptotic, and necrotic cells.
T71486 NS-0011
NS-0011 is an inhibitor of CDK5 translocation which increases CDK5 accumulation in the nucleus, suppressing both cancer cell proliferation and xenograft tumorigenesis.
TP1653 SV40 T-Ag-derived NLS peptide
This peptide, a nuclear localization signal DNA tagged to this peptide efficiently translocates into the cell nucleus.
T31016 Coumarin, 3-glyoxyloyl-8-methoxy- 3-Glyoxyloyl-8-methoxycoumarin,3-Glyoxyl-8-methoxycoumaric aldehyde
Coumarin, 3-glyoxyloyl-8-methoxy- is a coumarin analogue for treatment of various diseases. Substituting new functional groups at different positions of coumarin nucleus may be useful in the development of novel compound...
T24693 QD325 QD 325,QD-325
QD325 is a potent redox modulator for the Treatment of Pancreatic Ductal Adenocarcinoma. Nascent RNA sequencing following treatments with QD325 revealed induction of stress responses in the nucleus, endoplasmic reticulum...
T36024 FR179642 (hydrate) FR179642 (hydrate)
FR179642 is the cyclic peptide nucleus of the lipopeptide antifungal FR901379 and an intermediate in the synthesis of the echinocandin antifungal FK463 .1,2 1.Tomishima, M., Ohki, H., Yamada, A., et al.FK463, a novel wat...
T31015 Coumarin, 3-glyoxyloyl- 3-Glyoxylcoumaric aldehyde,3-Glyoxyloylcoumarin,Aldeide cumarin-3-gliossilica
Coumarin, 3-glyoxyloyl-, is a coumarin analogue for treatment of various diseases. Substituting new functional groups at different positions of coumarin nucleus may be useful in the development of novel compounds for the...
T37667 True Blue
True blue is a fluorescent neuronal retrograde tracer that labels the nucleus, nucleolus, cell body, proximal dendrites, and axons of neurons. It displays excitation/emission maxima of 373/404 nm, respectively.
T81698 NBD-LLLLpY
NBD-LLLLpY is a peptide synthesized enzymatically within the nucleus to selectively target and eliminate human induced pluripotent stem cells (hiPSCs).
TP1830L SV40 large T antigen NLS acetate Others
SV40 large T antigen NLS acetate is from Large T antigen residue 47 to 55, enables protein import into cell nucleus.
TP2215 Agouti-related Protein (AGRP) (25-82), human Others
Agouti-related peptide (AgRP) is a neuropeptide produced in the brain by the AgRP/NPY neuron. It is only synthesized in NPY containing cell bodies located in the ventromedial part of the arcuate nucleus in the hypothalam...
TP1830 SV40 large T antigen NLS
SV40 large T antigen NLS is from Large T antigen residue 47 to 55, enables protein import into cell nucleus. This peptide is generated from Large T antigen residue 47 to 55.
T37150 ADTN hydrobromide
ADTN hydrobromide (6,7-ADTN) is a dopamine receptor agonist (EC50s = 3.5 and 0.65 μM in rat striatal and nucleus accumbens homogenates, respectively). ADTN hydrobromide stimulates production of cAMP in rat striatal homog...
TP2073 BigLEN(mouse) BigLEN (mouse)
GPR171 agonist. ProSAAS-derived neuropeptide. Regulates food intake in mice. Inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus in a process dependent upon activation of postsynap...
T38980 Mg(II) protoporphyrin IX
Mg(II) protoporphyrin IX is a crucial compound in the synthesis of chlorophyll in Chlorella. It also serves as a negative regulator of nuclear photosynthetic gene expression. Additionally, Mg(II) protoporphyrin IX is emp...
TP1520 Hepatitis B Virus Core (128-140) Hepatitis B Virus Core 128-140
The hepatitis B virus (HBV) core protein has been found in the nucleus, the cytoplasm, or both of HBV-infected hepatocytes. nuclear localization of the HBV core protein is negatively regulated by phosphorylation during t...
T75963 Substance P(1-7) TFA
Substance P(1-7) TFA is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) TFA gives depressor and bradycardic effects when applied to the nucleus tractus solitarius [1] .
TP2045 CH 275
Potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin r...
T70399 TTC-352
TTC-352 is an orally bioavailable selective human estrogen receptor alpha (ERalpha; ESR1; ERa) partial agonist (ShERPA), with potential antineoplastic activity. Upon administration, TTC-352 mimics the naturally-occurring...
T12076L ML218 CCR
ML218 inhibits the burst activity in the subthalamic nucleus (STN) neurons. ML218 is an effective, selective, and orally active inhibitor of T-type Ca2+ channel (Cav3.1, Cav3.2, Cav3.3) (IC50s: 310 nM and 270 nM for Cav3...
T26564 ADCI SGB-017,SGB017,SGB 017
ADCI is an inhibitor of voltage-activated sodium channels and N-methyl-D-aspartate (NMDA)-receptor-gated channels. Inhibition of sodium channels by ADCI was voltage dependent. High doses of ADCI increased dopamine metabo...
T37131 MS 15203
Potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of forskolin activated adenylyl cyclase activity in rat hypothalamic memebranes). Exhibits minimal binding to a panel of ~70 GPCRs and 10 other re...
T82885 BigLEN(mouse) TFA
BigLEN(mouse) TFA is a proSAAS-derived neuropeptide and GPR171 agonist that both regulates food intake in mice and inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus, a mechanism ...
T27165 Diazaborine Diazaborine compound 2b18,Pkf 84.474,Pkf 84474,Pkf-84474,SA-84474
Diazaborine inhibits maturation of rRNAs for the large ribosomal subunit. Diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1. Diazaborine treatment causes, within minutes, a rapid redistribution of ...
TP1542 26Rfa, Hypothalamic Peptide, human
This human neuropeptide of the RFamide peptide family with orexigenic activity may be also involved in the control of feeding behavior. The 26RFa gene is exclusively expressed in the ventromedial hypothalamic nucleus and...
T70956 JNJ-pan-AR
JNJ-pan-AR, a meylated analogue of JNJ-63576253, is a novel pan-AR antagonist with potent activity against wild-type and clinically relevant AR mutations including F877L. JNJ63576253, also known as TRC253, is a potent an...
T75915 CTOP TFA
CTOP TFA is a potent and highly selective μ-opioid receptor antagonist. CTOP TFA antagonizes the acute analgesic effect and hypermotility. CTOP TFA enhances extracellular dopamine levels in the nucleus accumbens. CTOP TF...
T72646 Asperbisabolane L
Asperbisabolane L, a sesquiterpenoid, exerts the anti-inflammatory activity by inhibiting the NF-κB -activated pathway. Asperbisabolane L inhibits the translocation of NF-κB from cytoplasm to the nucleus. Asperbisabolane...
T74743 M47
M47 is a small molecule that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and en...
T75944 Spadin TFA
Spadin TFA, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with an IC 50 value of 10 nM. Spadin TFA enhances dorsal raphe nucleus 5-HT neurotransmission in mice and indu...
T70987 AT-1001
AT-1001 is an α3β4 nAChR partial agonist. AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats. AT-1001 also potently and reversib...

Compounds

ECBN HCL
T9264
Synonym: 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]echinocandin B hydrochloride (1:1)
Target: Others
DNQX
T7304
Synonym: FG 9041
Target: GluR, iGluR
DNQX disodium salt
T8459
Synonym: DNQX Disodium
Target: NMDAR, iGluR
4-Hydroxytamoxifen
T4420
Synonym: ICI 79280,(Z)-4-hydroxy Tamoxifen,trans-4-Hydroxytamoxifen
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
FG 7142
T11277
Synonym: ZK 39106,LSU-65
Target: GABA Receptor
AC-263093
T83651
Synonym:
Target: Neuropeptide Y Receptor
NIC3
T12220
Synonym:
Target: Others
KPT330,(E)-
T1844
Synonym: (E)-RN,KPT-330,KPT330,KPT 330
Target: Others, CRM1
Carbidine
T23854
Synonym: Carbidine dihydrochloride,Karbidin,Carbidin,Karbidine
Target: Others
SV40 T-Ag-derived NLS peptide acetate
TP1653L
Synonym: SV40 T-Ag-derived NLS peptide acetate(105425-98-7 free base)
Target: Others
Maribavir
T2162
Synonym: BW1263W94,GW257406X,Benzimidavir,1263W94
Target: Others, HCV Protease
Beclometasone dipropionate
T1127
Synonym: Beclovent,Beclomethasone dipropionate,Beconase,Vancenase
Target: Glucocorticoid Receptor
ZZL-7
T64317
Synonym:
Target: Serotonin Transporter
CWP232228
T10904
Synonym:
Target: Wnt/beta-catenin
PIN1 inhibitor API-1
T16538
Synonym:
Target: Others
Fludrocortisone acetate
T1666
Synonym: 9α-Fluorcortisol acetate,9α-Fludrocortisone acetate,9α-fluorocortisol acetate
Target: Glucocorticoid Receptor, Autophagy
Diflorasone
T2548
Synonym:
Target: Glucocorticoid Receptor
TSPA
T34963
Synonym:
Target:
RT-NH2
T19055
Synonym: Real Thiol-NH2
Target: Others
TO-PRO3 iodide
T34903
Synonym: TOPRO3 iodide,TO-PRO3 iodide salt
Target:
NS-0011
T71486
Synonym:
Target:
SV40 T-Ag-derived NLS peptide
TP1653
Synonym:
Target:
Coumarin, 3-glyoxyloyl-8-methoxy-
T31016
Synonym: 3-Glyoxyloyl-8-methoxycoumarin,3-Glyoxyl-8-methoxycoumaric aldehyde
Target:
QD325
T24693
Synonym: QD 325,QD-325
Target:
FR179642 (hydrate)
T36024
Synonym: FR179642 (hydrate)
Target:
Coumarin, 3-glyoxyloyl-
T31015
Synonym: 3-Glyoxylcoumaric aldehyde,3-Glyoxyloylcoumarin,Aldeide cumarin-3-gliossilica
Target:
True Blue
T37667
Synonym:
Target:
NBD-LLLLpY
T81698
Synonym:
Target:
SV40 large T antigen NLS acetate
TP1830L
Synonym:
Target: Others
Agouti-related Protein (AGRP) (25-82), human
TP2215
Synonym:
Target: Others
SV40 large T antigen NLS
TP1830
Synonym:
Target:
ADTN hydrobromide
T37150
Synonym:
Target:
BigLEN(mouse)
TP2073
Synonym: BigLEN (mouse)
Target:
Mg(II) protoporphyrin IX
T38980
Synonym:
Target:
Hepatitis B Virus Core (128-140)
TP1520
Synonym: Hepatitis B Virus Core 128-140
Target:
Substance P(1-7) TFA
T75963
Synonym:
Target:
CH 275
TP2045
Synonym:
Target:
TTC-352
T70399
Synonym:
Target:
ML218
T12076L
Synonym:
Target: CCR
ADCI
T26564
Synonym: SGB-017,SGB017,SGB 017
Target:
MS 15203
T37131
Synonym:
Target:
BigLEN(mouse) TFA
T82885
Synonym:
Target:
Diazaborine
T27165
Synonym: Diazaborine compound 2b18,Pkf 84.474,Pkf 84474,Pkf-84474,SA-84474
Target:
26Rfa, Hypothalamic Peptide, human
TP1542
Synonym:
Target:
JNJ-pan-AR
T70956
Synonym:
Target:
CTOP TFA
T75915
Synonym:
Target:
Asperbisabolane L
T72646
Synonym:
Target:
M47
T74743
Synonym:
Target:
Spadin TFA
T75944
Synonym:
Target:
AT-1001
T70987
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T3849 Kinsenoside (+)-Kinsenoside Apoptosis , Nrf2
Kinsenoside ((+)-Kinsenoside) shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury as well as improving its function, it cou...
T4104 Ophiopojaponin C Ophiopogonin C Others
Ophiopogonin C' pharmacological activities may be related to the substances in nucleus mainly.
T3S1692 Octahydrocurcumin Anti-infection , NF-κB , Reactive Oxygen Species , ROS
Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechanism of inhibiting NF-kB translocation to the nucleus. Octahy...
T5S1805 5,7-Dihydroxychromone 5,7-Dihydroxy-4H-Chromen-4-One Others , Virus Protease , PARP , Caspase , Nrf2
1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5,7-Dihydroxychromone exerts neuroprotective effect agai...
T1168 Desonide Tridesilon,Locapred,Prednacinolone Glucocorticoid Receptor
Desonide (Prednacinolone) is a synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated ...
T4809 Pyrimidine Metadiazine Others , Endogenous Metabolite
Pyrimidine (Metadiazine)s are heterocyclic, six-membered, nitrogen-containing carbon ring structures, with uracil, cytosine and thymine being the basal structures of ribose-containing nucleosides (uridine, cytidine, and ...
T0798 Triamcinolone Fluoxyprednisolone,Aristocort,Rodinolone Glucocorticoid Receptor , COX
Triamcinolone (Aristocort) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to transloca...
T6S1315 Oroxylin A 6-Methoxybaicalein,Baicalein 6-methyl ether Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production v...
T39077 Aeruginosin 865
Aeruginosin 865, isolated from terrestrial cyanobacterium Nostoc sp . Luke ová 30/93, is the first aeruginosin-type peptide containing both a fatty acid and a carbohydrate moiety. Aeruginosin 865 inhibits translocation o...
TN6394 Alisol B acetate
Alisol B acetate can induce Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells, the Bax activation and translocation from the cytosol to nucleus might be a crucial response to t...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-04753 IRE1 Protein, Human, Recombinant (aa 465-977) Human Baculovirus-Insect Cells
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ...
TMPY-04413 IRE1 Protein, Human, Recombinant (aa 465-977, His & GST) Human Baculovirus-Insect Cells
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ...
TMPY-02287 Ku70 & Ku80 Heterodimer Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
X-ray repair cross-complementing protein 5, also known as 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 8 kDa subunit, CTC box-binding factor 85 kDa subunit, DNA repa...
TMPY-04396 C-ABL/ABL1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy...
TMPJ-00261 TGF beta 2 Protein, Mouse/Rat, Recombinant Mouse,Rat Human Cells
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofaci...
TMPJ-00335 TGFBR2 Protein, Mouse, Recombinant (His) Mouse Human Cells
Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β regulates cellular processes by binding to three high-affinit...
TMPY-03722 EpCAM/TROP1 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane d...
TMPY-00382 Thioredoxin/TRX Protein, Mouse, Recombinant Mouse E. coli
Thioredoxin, also known as ATL-derived factor, Surface-associated sulphydryl protein, SASP and TXN, is a nucleus, cytoplasm and secreted protein that belongs to the thioredoxin family. Thioredoxins are proteins that act ...
TMPY-01691 Clusterin Protein, Human, Recombinant (CLU34, His) Human HEK293
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot...
TMPY-01694 Clusterin Protein, Mouse, Recombinant (His) Mouse HEK293
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot...
TMPY-03432 KEAP1 Protein, Human, Recombinant Human Baculovirus-Insect Cells
Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-02512 Alpha-Synuclein Protein, Human, Recombinant Human E. coli
Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associate...
TMPY-05587 EpCAM/TROP1 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane d...
TMPY-01300 EpCAM/TROP1 Protein, Human, Recombinant (His) Human HEK293
Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane d...
TMPY-03888 KEAP1 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-01477 MMP-2 Protein, Human, Recombinant Human HEK293
Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is de...
TMPY-02101 KEAP1 Protein, Human, Recombinant (His & GST & Avi) Human Baculovirus-Insect Cells
Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-01469 Frizzled 5 Protein, Human, Recombinant (His) Human HEK293
Wnt signaling is involved in a variety of embryonic development processes of nonvertebrates and vertebrates, where it determines cell motility, cell polarity, differentiation, proliferation and apoptosis, as well as form...
TMPY-01337 DLL4 Protein, Mouse, Recombinant (His) Mouse HEK293
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud...
TMPY-00776 DLL4 Protein, Human, Recombinant (hFc) Human HEK293
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud...
TMPY-01321 DLL4 Protein, Human, Recombinant (His) Human HEK293
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud...
TMPY-00021 PADI4 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Protein-arginine deiminase type-4, also known as HL-6 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type I V and PADI4, is a cytoplasm and nucleus protein that belongs to the protein arginine deiminase f...
TMPY-00835 IGFBP-3 Protein, Human, Recombinant (His) Human HEK293
The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth, differentiation, and proliferation. IGFBP3 is the most abundant IGF binding protein in human serum and is a growth inhibitory...
TMPY-04803 DLL4 Protein, Human, Recombinant Human HEK293
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud...
TMPY-05157 TGFBR2 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodoma...
TMPY-01461 EMAP-II/AIMP1 Protein, Human, Recombinant (His) Human E. coli
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, also known as Multisynthase complex auxiliary component p43, Endothelial monocyte-activating polypeptide II, AIMP1, EMAP2 and SCYE1, is a nucleus pro...
TMPY-02205 Beta-Catenin Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
beta-Catenin, also known as CTNNB1, is a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain, which is specialized for protein-protein binding. It is p...
TMPY-03286 HnRNP-R Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
HNRNP R, also known as HNRNPR, is an RNA binding protein. HNRNP R gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). HnRNPs complex with heterogeneous nuclear RNA (...
TMPH-01651 PRAME Protein, Human, Recombinant (His) Human Yeast
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid prote...
TMPH-01648 MED1 Protein, Human, Recombinant (His & SUMO) Human E. coli
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid prote...
TMPH-02111 SRP72 Protein, Human, Recombinant (GST) Human E. coli
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l...
TMPH-02115 KNSTRN Protein, Human, Recombinant (His) Human E. coli
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l...
TMPH-01444 Human herpesvirus 1 (HHV-1) (strain 17) ICP47 protein (His) HHV-1 E. coli
Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens prote...
TMPH-00553 Fructose 5-dehydrogenase [NADP(+)] Protein, Erwinia citreus, Recombinant (His & KSI) Erwinia citreus E. coli
Part of the tripartite complex that is required for the CDT activity. CdtB exhibits a DNA-nicking endonuclease activity, and very probably causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arres...
TMPH-02670 Gasdermin-A3 Protein, Mouse, Recombinant (His) Mouse E. coli
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or termin...
TMPH-02114 SMIM4 Protein, Human, Recombinant (His) Human in vitro E. coli expression system
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l...
TMPH-02120 SLC5A5 Protein, Human, Recombinant (His) Human E. coli
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l...
TMPH-00552 Lpp Protein, Erwinia amylovora, Recombinant (His & SUMO) Erwinia amylovora E. coli
CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells. CdtA, along with CdtC, probably forms a heterodimeric subunit required for ...
TMPJ-00718 AIF Protein, Human, Recombinant (His) Human E. coli
Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. During apoptosis, it is t...
TMPH-02121 SLC5A5 Protein, Human, Recombinant (B2M & His) Human E. coli
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l...
TMPH-02112 SMUG1 Protein, Human, Recombinant (His & SUMO) Human E. coli
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l...
TMPH-02113 SSNA1 Protein, Human, Recombinant (His) Human E. coli
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l...
TMPH-02122 SLC2A1 Protein, Human, Recombinant (His & Myc) Human E. coli
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l...
TMPK-00806 GHR/Growth Hormone R Protein, Human, Recombinant (His) Human HEK293
Pegvisomant, a growth hormone receptor (GHR) antagonist, is a well-known drug that was designed to treat acromegaly. However, recent studies have indicated that the GHR is a "moonlighting" protein that may exhibit dual f...
TMPH-03110 Erythropoietin Protein, Pig, Recombinant (His) Sus scrofa (Pig) Yeast
GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Essential for cell viability. By analogy with Ras, Ran may be activated when GTP i...
TMPH-03445 GSP1 Protein, S. cerevisiae, Recombinant (His) Saccharomyces cerevisiae Yeast
GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Essential for cell viability. By analogy with Ras, Ran may be activated when GTP i...
TMPJ-01408 HDGFRP3 Protein, Human, Recombinant (His) Human Human Cells
Hepatoma-Derived Growth Factor-Related Protein 3 (HDGFRP3) belongs to the HDGF family. HDGFRP3 can be found in testis, heart, spinal cord and brain. HDGFRP3 localizes to the nucleus and contains one PWWP domain. HDGFRP3 ...
TMPH-01527 NAALADL2 Protein, Human, Recombinant (His) Human E. coli
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localizat...
TMPY-03700 S100A11 Protein, Mouse, Recombinant (His) Mouse E. coli
Protein S100-A11, also known as S100 calcium-binding protein A11, S100A11 and MLN70, is a member of theS-100 family. S100A11 is widely expressed in multiple tissues, and is located in cytoplasm, nucleus, and even cell pe...
TMPY-01331 S100A11 Protein, Human, Recombinant Human E. coli
Protein S100-A11, also known as S100 calcium-binding protein A11, S100A11 and MLN70, is a member of theS-100 family. S100A11 is widely expressed in multiple tissues, and is located in cytoplasm, nucleus, and even cell pe...
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IRE1 Protein, Human, Recombinant (aa 465-977)
TMPY-04753
Species: Human
Expression System: Baculovirus-Insect Cells
IRE1 Protein, Human, Recombinant (aa 465-977, His & GST)
TMPY-04413
Species: Human
Expression System: Baculovirus-Insect Cells
Ku70 & Ku80 Heterodimer Protein, Human, Recombinant (His)
TMPY-02287
Species: Human
Expression System: Baculovirus-Insect Cells
C-ABL/ABL1 Protein, Human, Recombinant (GST)
TMPY-04396
Species: Human
Expression System: Baculovirus-Insect Cells
TGF beta 2 Protein, Mouse/Rat, Recombinant
TMPJ-00261
Species: Mouse,Rat
Expression System: Human Cells
TGFBR2 Protein, Mouse, Recombinant (His)
TMPJ-00335
Species: Mouse
Expression System: Human Cells
EpCAM/TROP1 Protein, Cynomolgus, Recombinant (His)
TMPY-03722
Species: Cynomolgus
Expression System: HEK293
Thioredoxin/TRX Protein, Mouse, Recombinant
TMPY-00382
Species: Mouse
Expression System: E. coli
Clusterin Protein, Human, Recombinant (CLU34, His)
TMPY-01691
Species: Human
Expression System: HEK293
Clusterin Protein, Mouse, Recombinant (His)
TMPY-01694
Species: Mouse
Expression System: HEK293
KEAP1 Protein, Human, Recombinant
TMPY-03432
Species: Human
Expression System: Baculovirus-Insect Cells
Alpha-Synuclein Protein, Human, Recombinant
TMPY-02512
Species: Human
Expression System: E. coli
EpCAM/TROP1 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-05587
Species: Human
Expression System: HEK293
EpCAM/TROP1 Protein, Human, Recombinant (His)
TMPY-01300
Species: Human
Expression System: HEK293
KEAP1 Protein, Human, Recombinant (His & GST)
TMPY-03888
Species: Human
Expression System: Baculovirus-Insect Cells
MMP-2 Protein, Human, Recombinant
TMPY-01477
Species: Human
Expression System: HEK293
KEAP1 Protein, Human, Recombinant (His & GST & Avi)
TMPY-02101
Species: Human
Expression System: Baculovirus-Insect Cells
Frizzled 5 Protein, Human, Recombinant (His)
TMPY-01469
Species: Human
Expression System: HEK293
DLL4 Protein, Mouse, Recombinant (His)
TMPY-01337
Species: Mouse
Expression System: HEK293
DLL4 Protein, Human, Recombinant (hFc)
TMPY-00776
Species: Human
Expression System: HEK293
DLL4 Protein, Human, Recombinant (His)
TMPY-01321
Species: Human
Expression System: HEK293
PADI4 Protein, Human, Recombinant (His)
TMPY-00021
Species: Human
Expression System: Baculovirus-Insect Cells
IGFBP-3 Protein, Human, Recombinant (His)
TMPY-00835
Species: Human
Expression System: HEK293
DLL4 Protein, Human, Recombinant
TMPY-04803
Species: Human
Expression System: HEK293
TGFBR2 Protein, Human, Recombinant (His)
TMPY-05157
Species: Human
Expression System: Baculovirus-Insect Cells
EMAP-II/AIMP1 Protein, Human, Recombinant (His)
TMPY-01461
Species: Human
Expression System: E. coli
Beta-Catenin Protein, Human, Recombinant (His & GST)
TMPY-02205
Species: Human
Expression System: Baculovirus-Insect Cells
hnRNP-R Protein, Human, Recombinant (His & GST)
TMPY-03286
Species: Human
Expression System: Baculovirus-Insect Cells
PRAME Protein, Human, Recombinant (His)
TMPH-01651
Species: Human
Expression System: Yeast
MED1 Protein, Human, Recombinant (His & SUMO)
TMPH-01648
Species: Human
Expression System: E. coli
SRP72 Protein, Human, Recombinant (GST)
TMPH-02111
Species: Human
Expression System: E. coli
KNSTRN Protein, Human, Recombinant (His)
TMPH-02115
Species: Human
Expression System: E. coli
Human herpesvirus 1 (HHV-1) (strain 17) ICP47 protein (His)
TMPH-01444
Species: HHV-1
Expression System: E. coli
Fructose 5-dehydrogenase [NADP(+)] Protein, Erwinia citreus, Recombinant (His & KSI)
TMPH-00553
Species: Erwinia citreus
Expression System: E. coli
Gasdermin-A3 Protein, Mouse, Recombinant (His)
TMPH-02670
Species: Mouse
Expression System: E. coli
SMIM4 Protein, Human, Recombinant (His)
TMPH-02114
Species: Human
Expression System: in vitro E. coli expression system
SLC5A5 Protein, Human, Recombinant (His)
TMPH-02120
Species: Human
Expression System: E. coli
Lpp Protein, Erwinia amylovora, Recombinant (His & SUMO)
TMPH-00552
Species: Erwinia amylovora
Expression System: E. coli
AIF Protein, Human, Recombinant (His)
TMPJ-00718
Species: Human
Expression System: E. coli
SLC5A5 Protein, Human, Recombinant (B2M & His)
TMPH-02121
Species: Human
Expression System: E. coli
SMUG1 Protein, Human, Recombinant (His & SUMO)
TMPH-02112
Species: Human
Expression System: E. coli
SSNA1 Protein, Human, Recombinant (His)
TMPH-02113
Species: Human
Expression System: E. coli
SLC2A1 Protein, Human, Recombinant (His & Myc)
TMPH-02122
Species: Human
Expression System: E. coli
GHR/Growth Hormone R Protein, Human, Recombinant (His)
TMPK-00806
Species: Human
Expression System: HEK293
Erythropoietin Protein, Pig, Recombinant (His)
TMPH-03110
Species: Sus scrofa (Pig)
Expression System: Yeast
GSP1 Protein, S. cerevisiae, Recombinant (His)
TMPH-03445
Species: Saccharomyces cerevisiae
Expression System: Yeast
HDGFRP3 Protein, Human, Recombinant (His)
TMPJ-01408
Species: Human
Expression System: Human Cells
NAALADL2 Protein, Human, Recombinant (His)
TMPH-01527
Species: Human
Expression System: E. coli
S100A11 Protein, Mouse, Recombinant (His)
TMPY-03700
Species: Mouse
Expression System: E. coli
S100A11 Protein, Human, Recombinant
TMPY-01331
Species: Human
Expression System: E. coli
Cat No. Product Name
L3700 JAK-STAT Compound Library

256 compounds
A unique collection of 256 JAK/STAT signaling targeted compounds for high throughput and high content screening;
L4100 TGF-beta/Smad Compound Library

185 compounds
A unique collection of 185 TGF-beta/Smad signaling targeted compounds for high throughput and high content screening;
L4700 Immunology/Inflammation Compound Library

3483 compounds
A unique collection of 3483 anti-inflammation compounds effective for high throughput screening and high content screening.
L1310 Cytoskeletal Signaling Pathway Compound Library

773 compounds
A unique collection of 773 cytoskeleton-related compounds, can be used for HTS and HCS;
L3800 NF-κB Signaling Compound Library

740 compounds
A unique collection of 740 compounds targeting NF-κB signaling for high throughput screening and high content screening;
TargetMol