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Results for "
npc 15437 (hydrochloride)
" in TargetMol Product Catalog- Inhibitors & Agonists1
NPC-15437 dihydrochloride
NPC15437 dihydrochloride
T37480141774-20-1
NPC-15437 dihydrochloride is a synthetic prototype belonging to a novel structural class of protein kinase C (PKC) inhibitors. NPC 15437 potently inhibits PKC enzymatic activity and phorbol ester binding with IC50 values around 19 μM and 23 μM, respectively, without affecting cAMP-dependent or Ca2+/calmodulin-dependent kinases at concentrations up to 300 μM, thereby demonstrating selectivity for PKC and serving as an important tool compound for dissecting PKC-mediated cellular signaling mechanisms.
- $166
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