non-acidic

Expression system: E. coli
Length: 1-761, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 2-224, Full Length of Mature Protein
Activity: Not Tested

Bone sialoprotein 2(IBSP) is a monomeric non‑collagenous member of the SIBLING family of extracellular matrix proteins. It is principally associated with the early stages of bone mineralization. Mouse IBSP is synthesized as a 324 amino acid (aa) precursor that contains a 16 aa signal sequence and a 308 aa mature region. The mature segment is divided into a basic N‑terminus (aa 17 ‑ 62), a central region (aa 63 ‑ 233), and an acidic C‑terminus (aa 234 ‑ 317). IBSP is highly glycosylated, sulfated and phosphorylated. Phosphorylation promotes HAp nucleation, while carbohydrate may regulate cell adhesion. IBSP binds tightly to hydroxyapatite, appears to form an integral part of the mineralized matrix. It is probably important to cell-matrix interaction and promotes Arg-Gly-Asp-dependent cell attachment.

Expression system: E. coli
Length: 292-432, Partial
Activity: Not Tested

Secreted protein acidic and rich in cysteine (SPARC osteonectin BM40) is one of the most abundant non-collagenous protein expressed in mineralized tissues.The capacity of SPARC to influence pathways involved in extracellular matrix assembly such as procollagen processing and collagen fibril formation as well as the capacity to influence osteoblast differentiation and osteoclast activity will be addressed.

Expression system: HEK293 Cells
Length: 21-141, Full Length of Mature Protein
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 1-419, Full Length
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 1-337, Full Length
Activity: Enzyme activity