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(1)
By Target- Autophagy
- Beta Amyloid(1)
- LDLR(1)
- Wnt/beta-catenin(1)
- Others(1)
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Results for "
neuropathology
" in TargetMol Product Catalog.- Inhibitors & Agonists2
- Dye Reagents1
CitedSJ-300
T2146521210357-06-4
SJ-300 is a selective, orally active DKK3-LRP1 inhibitor capable of crossing the blood-brain barrier. It binds to mLRPIV with a Kd of 7.9 μM and inhibits the DKK3-mLRPIV complex with an IC50 of 3.2 μM, without affecting the interaction between Aβ and LRP1. In Alzheimer's disease models, SJ-300 restores Aβ clearance functionality, improves cognitive function, and reduces neuropathology by approximately 73.3% (Aβ plaque reduction). SJ-300 is suitable for research related to Alzheimer's disease.
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