neural disorders

methyl isoeugenol (MIE) is a natural food flavour that constitutes 93.7% of an essential oil from Pimenta pseudocaryophyllus leaf. The leaf extracts of this species are used as a calming agent. As a ubiquitous food additive, the application of MIE for tre

ar-Turmerone is a natural volatile organic compound extracted from the rhizomes of turmeric (Curcuma longa). ar-Turmerone exhibits oral bioavailability and possesses biological activities such as antitumor, anti-inflammatory, antioxidant, and neuroprotective effects. ar-Turmerone exerts a positive regulatory effect on dendritic cells in mice. Ar-turmerone can induce neural stem cell proliferation both in vitro and in vivo, making it useful for research on neurological disorders. Ar-turmerone induces apoptosis in U937 cells.

(8R)-8-Hydroxyepoxyboetirane A is a neuroactivating compound that interacts with PKCδ-C1B. This compound binds into the PKC enzyme pocket through hydrogen bonds with glycine-253, leucine-251, and threonine-242. It induces the release of NRG1 and promotes the differentiation of neural stem cells into neurons. (8R)-8-Hydroxyepoxyboetirane A holds potential for research into nervous system disorders.

PUC-55 is a 5-HT6R antagonist with a Ki of 37.5 nM, capable of inducing autophagy (Autophagy) in neural cells by inhibiting the mTOR pathway, making it useful for research in the field of neurological disorders.

H27485 is a high-affinity dopamine transporter (DAT) inhibitor (Ki = 6.3 nM) that modulates neural signaling by blocking dopamine reuptake; it is commonly used in pharmacological studies of the dopaminergic system and related neurological disorders.

Neuroprotective agent 14 is a 1H-benzimidazole [d] compound that can penetrate the blood-brain barrier and is known for its neuroprotective properties. It activates autophagy (autophagy) and reduces the accumulation of SCMAS in iPSC-derived neural progenitor cells. This agent is useful for studying neurological disorders such as neuronal ceroid lipofuscinoses (NCLs).

Neuroprotective agent 13 is a 1H-benzimidazole [d] class compound with neuroprotective properties that can penetrate the blood-brain barrier. It activates autophagy (autophagy) and mitigates the accumulation of SCMAS in induced pluripotent stem cell (iPSC) derived neural progenitor cells. Neuroprotective agent 13 is applicable in the study of neurological disorders such as neuronal ceroid lipofuscinoses (NCLs).

Trk Bactivator-1 D3 is a specific, orally active activator of tropomyosin receptor kinase B (TrkB) that can penetrate the blood-brain barrier. By activating the brain-derived neurotrophic factor (BDNF)-TrkB-cAMP response element-binding protein (CREB) signaling pathway, TrkBactivator-1 exhibits potent antidepressant effects and enhances neural plasticity. It is applicable for research into neurological disorders such as depression.