nadph dehydrogenase

Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and no intrinsic sympathomimetic activity.

RV01 is a novel quinoline-substituted analogue of resveratrol that inhibits DNA damage, reduces ethanol-induced acetaldehyde dehydrogenase (ALDH2) mRNA expression, and has hydroxyl radical scavenging activity. rV01 reduces iNOS expression and has anti-neuroinflammatory effects. rV01 reduces tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) mRNA levels and secretion. RV01 reduced tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) mRNA levels and secretion, inhibited lps-induced ROS production and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation, decreased toll-like receptor 4 (TLR4) protein expression, and inhibited lps-induced activation of mitogen-activated protein kinase (MAPK) and nuclear transcription factor-кB (NF-кB) signaling pathways.

6PGD-IN-2 is a non-competitive inhibitor of 6-phosphogluconate dehydrogenase (6PGD) with an IC50 value of 5.1 μM. It disrupts 6PGD oligomerization in a substrate-dependent manner and induces the production of NADPH and Ru-5-P while reducing DNA synthesis in A549 cells. 6PGD-IN-2 is applicable in research on non-small cell cancer and liver cancer.

(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), which can be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner, enhancing the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, thereby increasing survival time.

Glucose-6-phosphate dehydrogenase is a rate-controlling enzyme of the pentose phosphate pathway (PPP) that catalyzes the oxidative dehydrogenation of glucose-6-phosphate to produce glucose-6-phosphate and NADPH.It is a sex-linked metabolic enzyme involved in the shunting of hexose monophosphate.

Glucose dehydrogenase (GDH) is an oxidoreductase enzyme that facilitates the oxidation of β-D-glucose into β-D-glucono-1,5-lactone, while concurrently reducing cofactor NADP+ to NADPH, and to a lesser degree, NAD+ to NADH. It can utilize both NAD+ and NADP+ as cofactors and serves in the regeneration of NADH and NADPH [1] [2].

Glucose dehydrogenase, Pseudomonas sp. (EC 1.1.1.47) is a type of oxidoreductase that acts on the CH-OH group of donor molecules, utilizing either NAD+ or NADP+ as the acceptor. The enzyme's three substrates are β-D-glucose, NAD+, and NADP+, and its four products are D-glucono-1,5-lactone, NADH, NADPH, and H+.

6-Phosphogluconic Dehydrogenase, Sheep (EC 1.1.1.44) is an enzyme in the oxidoreductase family that acts on the CH-OH group of donor molecules using NAD+ or NADP+ as an acceptor. The enzyme's substrates are 6-phospho-D-gluconate and NADP+, and its products are D-ribulose-5-phosphate, CO2, and NADPH.

3α-Hydroxysteroid Dehydrogenase, Pseudomonas testosteroni (EC 1.1.1.50), is part of the oxidoreductase family. This enzyme utilizes three substrates: androsterone, NAD+, and NADP+, resulting in four products: 5α-androstan-3,17-dione, NADH, NADPH, and H+. It acts on the CH-OH group of donor molecules using NAD+ or NADP+ as an acceptor.

Yeast 6-Phosphogluconic Dehydrogenase (EC 1.1.1.44) is a member of the oxidoreductase family, which acts on the CH-OH group of donor molecules using NAD+ or NADP+ as an acceptor. The two substrates for Yeast 6-Phosphogluconic Dehydrogenase are 6-phospho-D-gluconate and NADP+, and its three products are D-ribulose 5-phosphate, CO2, and NADPH.

Glucose-6-phosphate dehydrogenase, Torula yeast (EC 1.1.1.49), is a cytosolic enzyme involved in the pentose phosphate pathway. This metabolic pathway supports cells, such as red blood cells, by providing reducing power through the maintenance of nicotinamide adenine dinucleotide phosphate (NADPH) levels.