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By Target- Isocitrate Dehydrogenase (IDH)
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Results for "
mutant isocitrate dehydrogenase(midh)
" in TargetMol Product Catalog- Inhibitors & Agonists2
Vorasidenib
PVM MA, AG-881
T73071644545-52-7
Vorasidenib (PVM MA) is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively)
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AGI-026
AGI-12026, AGI12026, AGI026, AGI 026
T265751446501-77-4
AGI-026 (AGI-12026) is a novel and potent dual inhibitor of the mutant isocitrate dehydrogenase mIDH1 2 with the advantages of oral administration and penetration of the blood-brain barrier, with a drug concentration to plasma concentration ratio (brain plasma ratio) of 1.5 in brain tissue, and the ability to reduce the accumulation of the carcinogenic metabolite d-2-hydroxyglutarate (2-HG), which is used in the study of mIDH gliomas.
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