mosaic

Piperonylic acid (2H-1,3-benzodioxole-5-carboxylic acid) is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic acid selectively inactivate the CYP73A P450 subpopulation.

Yadanziolide A is a natural product isolated from the cultivated dry seeds of Brucea javanica, has strong antiviral activities with IC50 of 5.5 μM against tobacco mosaic virus. Yadanziolide A shows significant antitumor effects.

Pymetrozine (CGA 215944) is a Homoptera feeding inhibitor that effectively prevents transmission of the cauliflower mosaic caulimovirus by the aphid species Myzus persicae.

TMV-IN-11 (compound syn-3g), a potent inhibitor of Tobacco Mosaic Virus (TMV), exhibits strong inactivation properties with an IC 50 value of 120.7 μg/mL. This compound successfully suppresses TMV expression.

TMV-IN-12 (compound4) serves as an inhibitor targeting Tobacco Mosaic Virus (TMV) and possesses antifungal properties. It effectively prevents the aggregation of TMV particles and the self-assembly of TMV coat protein (TMV-CP) with a dissociation constant (Kd) of 0.142 μM, thereby inhibiting TMV infections in tobacco plants.

TMV-IN-7 (compound G2) is a potent inhibitor of Tobacco Mosaic Virus (TMV). It exhibits strong hydrophobic interactions that prevent the virus from self-assembling.

Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities. It is a plant growth regulator that induces malformations in plant structure. Malformin A inhibits replication of tobacco mosaic virus (TMV) in local lesion and leaf-disc assays (IC50s = 19.7 and 45.4 μg/ml, respectively). It is cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively), inhibits proliferation of PC3 and LNCaP cells (IC50s = 130 and 90 nM, respectively), and induces apoptosis and necrosis in PC3 and LNCaP cells. Malformin A also increases the accumulation of reactive oxygen species, decreases the mitochondrial membrane potential, and induces autophagy in PC3 and LNCaP cells. It is toxic to mice when administered intraperitoneally (LD50 = 3.1 mg/kg) but not orally up to doses of 50 mg/kg.

(±)-Phrymarolin II is a promising class of inhibitors that target the tobacco mosaic virus, representing a novel approach in plant virus suppression.

Antiviral agent 14 is an antiviral compound that inhibits tobacco mosaic virus (TMV) with an EC50 of 135.5 μg/mL and cucumber mosaic virus (CMV) with an EC50 of 178.6 μg/mL.

Lobaric acid is a depsidone metabolite isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activities. It scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol), inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 μg/ml), inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 0.87 μM for the human recombinant enzyme), and inhibits production of 12(S)-HETE [Item No. 34570] by 12(S)-lipoxygenase (IC50 = 28.5 μM). In vivo, lobaric acid (250 μM) reduces lesion number, but not lesion diameter, in tobacco leaves infected with tobacco mosaic virus (TMV).

TMV-IN-1, a chalcone derivative, serves as an inhibitor of the tobacco mosaic virus (TMV), demonstrating effective therapeutic and protective activities, with EC50 values of 70.7 μg/mL and 60.8 μg/mL, respectively. This compound is applicable in research related to infection, inflammation, and tumor [1].

TMV-IN-2, a chalcone derivative, functions as an inhibitor of the tobacco mosaic virus (TMV), exhibiting antiviral properties with an EC50 of 89.9 μg/mL. This compound is utilized in investigating infection, inflammation, and tumor research [1].

TMV-IN-3, a chalcone derivative, functions as a tobacco mosaic virus (TMV) inhibitor, exhibiting antiviral activity against TMV with an EC50 of 120.3 μg/mL. This compound is applicable for research in infection, inflammation, and tumor [1].

TMV-IN-4 (Compound 3), a tobacco mosaic virus (TMV) inhibitor, effectively strengthens plant resistance and tolerance to TMV by binding with the TMV helicase. Furthermore, it boosts activities of peroxidase and superoxide dismutase, augmenting tobacco's resilience to TMV infection [1].

TMV-IN-5 (compound 1a) is an antiviral and antifungal agent that inhibits the assembly of the tobacco mosaic virus (TMV) by binding to its coat protein (CP), making it a potential candidate for pesticide formulations [1].

TMV-IN-6 (Compound 4g) is a novel antiviral and fungicidal agent that obstructs tobacco mosaic virus (TMV) assembly by binding to the TMV coat protein (CP) and disrupting the interaction between TMV CP and RNA [1].

Chaparrinone, a bittersweet analog from Ailanthus altissima (Mill.), has antimalarial, antitumor, and antiviral activities and has been used in the study of tobacco mosaic virus infections and SARS virus infections.

7-Deoxy-trans-dihydronarciclasine is an alkaloid that functions as a tobacco mosaic virus (TMV) inhibitor with an IC50 of 1.80 μM and also serves as an anti-neuroinflammatory agent. This compound reduces Aβ and APP levels in the cerebral cortex of Tg2576 mice [1] [2] [3].

TMV-IN-8 (compound 7d) is an anti-tobacco mosaic virus (TMV) agent with an antiviral EC50 of 157.6 μg/mL. TMV-IN-8 blocks the assembly of TMV by binding with coat protein (Kd = 0.7 μM) and suppresses TMV coat protein gene expression and biosynthesis process [1].

Trans-3-(3-Pyridyl)acrylic acid (compound 15) is a trans-3-aryl acrylic acid demonstrating antiviral activity against tobacco mosaic virus (TMV) [1].

TMV-IN-9 (compound A6) is an antiviral agent that exhibits exceptional inactivation effects against Tobacco Mosaic Virus (TMV), with an EC50 of 62.8 μg/mL. It demonstrates strong binding capabilities to the TMV capsid protein, with a binding affinity of 1.862 μM. Moreover, TMV-IN-9 significantly disrupts the integrity of TMV particles, thereby preventing the virus from infecting the host.

TMV-IN-10 (compound 4h), a derivative of arecoline, exhibits antiviral activity against Tobacco Mosaic Virus (TMV) with an EC50 value of 146 µg/mL. It functions by targeting the viral coat protein (CP), causing the virus to fragment. This compound is useful for research into pest control and increasing crop yields.

DL-Serine-2,3,3-D3 is a deuterated form of DL-Serine. This compound is a fundamental metabolite and a mixture of D-Serine and L-Serine. It exhibits antiviral properties, effectively inhibiting the proliferation of Tobacco Mosaic Virus (TMV).

DL-Serine-2,3,3-d3 (Standard) is a reference standard of DL-Serine-2,3,3-d3 intended for quantitative analysis, quality control, and related biochemical research applications. DL-Serine-2,3,3-d3 is a deuterated form of DL-Serine. This compound is a fundamental metabolite and a mixture of D-Serine and L-Serine. It exhibits antiviral properties, effectively inhibiting the proliferation of Tobacco Mosaic Virus (TMV).