moa

MOA-stilbene, also known as 3-Methoxy-2-(2-styrylphenyl)propenic acid methyl ester, is a fluorescence inhibitor. MOA-stilbene is a new tool for investigation of the reactions of the chloroplast cytochrome bf complex. MOA-stilbene is known to be a specific inhibitor of the Qo site of mammalian cytochrome bc 1 complex.

Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.

Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug due to its inhibition of Wnt β-catenin pathway in some types of cancer.

Hydroxyzine Pamoate (Bobsule) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.

8-Bromoadenosine is an adenosine derivative in which the hydrogen atom on the amino group is replaced by a bromine atom for the synthesis of nucleotides with specific biological activities. 8-Br-Adenosine exhibits a variety of biological activities in vitro, including inhibition of mitochondrial membrane potential, cytoplasmic Ca²⁺ levels, and RNA and protein synthesis.

2-Bromoacetamide (α-Bromoacetamide) is an emerging unregulated disinfection by-product showing developmental toxicity in animals. It inactivates alcohol dehydrogenase.

Oxantel Pamoate (Oxantel embonate) is used as an Antinematodal agent.

Pyrantel pamoate (Pyrantel embonate) is a depolarizing neuromuscular blocking agent. This compound is commonly used as an anthelmintic to treat parasitic worm infections, effectively paralyzing nematodes by inhibiting their neuromuscular activity.

Bromoacetamido-PEG9-ethylcarbamoyl-C4-Boc is a polyethylene glycol (PEG)-based proteolysis targeting chimera (PROTAC) linker used in the synthesis of PROTACs[1].

N-Bromoacetyl-β-alanine is an alkyl chain-derived PROTAC linker used in synthesizing PROTACs[1] and serves as a cleavable ADC linker in the production of antibody-drug conjugates (ADCs)[2].

Bromoacetamido-PEG5-azide is a polyethylene glycol (PEG)-based linking molecule, commonly known as a PROTAC linker, which is utilized for the efficient synthesis of PROTACs[1].

1,1,3-Tribromoacetone (1,1,3-tribromo-2-propanone) is an impurity of methotrexate.

1,1-Dibromoacetone is a dibromide derivative of bromoacetone.

Bromoacetamido-PEG4-NHS ester is a PEGylated N-hydroxysuccinimide ester linker designed for PROTAC synthesis, facilitating the creation of protein-targeted chimeras (PROTACs)[1].

N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker used in the synthesis of PROTACs and antibody-drug conjugates (ADCs) [1, 2], serving as a cleavable ADC linker to facilitate drug-antibody conjugation for targeted delivery [2].

Homoarbutin is a natural product

Nucleoside Derivatives - Halo-nucleosides; 2-Modified purine nucleosides; Scaffolds and Templates; Drugs and Inhibitors; Antimalarial agent

Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. It is also used as therapy for gender identity disorder.

8-Bromoadenine (8-Bromo-9H-purin-6-amine) functions as a radiosensitizer for DNA and hinders the repair of single-strand breaks within cells. It is a brominated derivative of adenine and can be used to produce radioactive adenine by replacing bromine with deuterium.

4’-Bromoacetophenone is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

1-Bromoadamantane is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Homoanserine Nitrate is a dipeptide found in mammalian brains and muscles.

L-Azidohomoalanine, an alkyl chain-derived PROTAC linker, is utilized in the synthesis of PROTACs[1].

Bromoacetamido-PEG9-ethylcarbamoyl-C8-Boc represents a PEG-based PROTAC linker suitable for synthesizing PROTACs[1].