mmaf ome

MMAF-OMe (Monomethyl auristatin F methyl ester) is an antitubulin agent which inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively. MMAF-Ome is also an ADC cytotoxin.

Fmoc-MMAF-OMe is a tubulin polymerization inhibitor and anticancer agent featuring an Fmoc protecting group. Its active component, MMAF, serves as the cytotoxic (ADC Cytotoxin) element in conventional antibody-drug conjugates (ADCs) [1].

Acetylene-PEG3-MMAF-OMe (LCB14-0536) is a protein-active agent conjugate identifiable by isoprenoid transferase. It serves as a click chemistry reagent containing an Alkyne group that undergoes a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules that possess an Azide group.