ml-204

ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.

ML204 hydrochloride (ML204 HCl) is a selective and potent TRPC4/TRPC5 channel antagonist that blocks TRPC4β currents activated by intracellular dialysis via μ-opioid receptor stimulation or guanosine 5'-3-O-(thio)trisphosphate (GTPgammaS).

Tilapia piscidin 3, an antimicrobial peptide, exhibits antibacterial properties effective against both gram-positive and gram-negative bacteria. It has demonstrated minimum inhibitory concentrations (MICs) of 2.44 µg/mL for V. vulnificus 204 and V. alginolyticus, 9.78 µg/mL for S. agalactiae 819, 19.55 µg/mL for E. faecalis BCRC 10066, and 0.61 µg/mL for S. agalactiae BCRC 10787. Additionally, it presents hemolytic activity on fish red blood cells [1].