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mglur2 pam

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  • Inhibitors & Agonists
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    TargetMol | Inhibitors_Agonists
JNJ-42153605
T34511254977-87-1
JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).
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LY487379
T62756353231-17-1
LY487379 is a selective human mGluR2 positive allosteric modulator (PAM) that enhances glutamate-stimulated [35 S] GTPγS binding to mGlu2 receptors (EC50: 1.7 μM) and mGlu3 receptors (EC50 >10 μM). LY487379 induces cognitive flexibility and behavioral inhibition in a rat model and can be used to study schizophrenia.
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7-10 days
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