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Results for "
mglur2 pam
" in TargetMol Product Catalog.- Inhibitors & Agonists2
JNJ-42153605
T34511254977-87-1
JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).
- $31
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LY487379
T62756353231-17-1
LY487379 is a selective mGluR2 positive allosteric modulator (PAM). It potently enhances glutamate-stimulated signaling, with EC50 values of 1.7 μM for mGlu2 and >10 μM for mGlu3 receptors, demonstrating high subtype selectivity. In behavioral models, LY487379 has been shown to promote cognitive flexibility and facilitate behavioral inhibition. It serves as a valuable tool for researching the therapeutic potential of mGluR2 modulation in schizophrenia and related cognitive impairments.
- $40
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