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1-(3,4-Dihydroxyphenyl)-1-propanol, 3?,4?-Di-Me et is a useful organic compound for research related to life sciences and the catalog number is T130490.

3-AP-Me is the dimethyl derivative of the ribonucleotide reductase inhibitor 3-AP (SML0568). It activates the endoplasmic reticulum (ER) stress pathway by promoting eIF2α phosphorylation and upregulating gene expression of transcription factors ATF4 and ATF6, thereby inducing apoptosis. Additionally, 3-AP-Me activates cellular stress kinases c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase, leading to the upregulation of spliced mRNA variant XBP1. It is applicable in cancer research.

3’-Me Meayamycin D is a splice modulator that targets SF3B1 and PHF5A, affecting the pre-mRNA splicing process and downregulating MCL-1 expression. It inhibits the proliferation of cancer cell lines HCT116, SW48, A549, DMS53, and DMS114, with a GI50 range of 4.6-7.2 nM. In mice, it demonstrates good plasma stability with a half-life of 16 hours.

Fmoc-Lys(Me)3-OH Chloride, with catalog number T65200 and CAS number 201004-29-7, is a valuable organic compound for life sciences research.

Fmoc-His(3-Me)-OH is an amino acid derivative and has a wide range of applications in life science related research.

2'-O-Me-5-I-U-3'-phosphoramidite, a purine nucleoside analog, exhibits extensive antitumor activity primarily against indolent lymphoid malignancies through mechanisms such as DNA synthesis inhibition and apoptosis induction, among others [1].

5-Benzylaminocarbony-3'-O-Ac-2'-O-Me-5'-O-DMT-uridine is a 5 modified pyrimidine nucleoside; 2'-O-Methyl nucleoside.

2'-O-Me-2-thio-U-3'-phos phoramidite is a Nucleoside Phosphoramidite.

3'-O-Me-U-2'-phosphoramidite is a Nucleoside Phosphoramidite.

3'-O-Me-C(Bz)-2'-phosphoramidite is a Nucleoside Phosphoramidite.

3'-O-Me-G(iBu)-2'-phosphoramidite is a Nucleoside Phosphoramidite.

5-Me-3'-dU-2'-phosphoramidite is a Nucleoside Phosphoramidite.

3-Me-5-OMe-UTP sodium is a labeled and modified deoxyoligonucleotide (dNTP) that can release pyrophosphate and generate fluorescence during gene synthesis and sequencing, so it has special application value.

3'-O-Me-m7G(5')ppp(5')A (ARCAcap) solution (100mM) is an anti-reverse cap analog (ARCA) with a unique RNA cap structure. This RNA cap structure is a common feature of mRNA in certain RNA viruses and eukaryotes, serving as a signal for the initiation of translation.

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(m-tolyl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65860 and the CAS number is 211637-74-0.

1. Methyl eugenol (4-allylveratrole) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents, in view of the carcinogenic potential of ME, the need to check its presence in food products with effective analytical methods. 2. Methyleugenol has insecticidal properties. 3. Methyleugenol can inhibit the production of nitric oxide and decreased the protein expression of inducible nitric oxide synthase, it down-regulates the production of pro-inflammatory cytokines in the ischemic brain as well as in immunostimulated mixed glial cells; indicates that methyleugenol could be useful for the treatment of ischemia/inflammation-related diseases. 4. Methyleugenol has cytotoxicity and genotoxicity. 5. Intravenous (i.v.) treatment with methyleugenol (ME) in either anesthetized or conscious rats elicits hypotension, an effect that seems related to an active vascular relaxation rather than withdrawal of sympathetic tone. 6. Methyleugenol has antinociceptive effect on the second phase of formalin-induced pain, may be due to the inhibition of N-methyl-d-aspartic acid (NMDA) receptor-mediated hyperalgesia via GABA(A) receptors. 7. Methyleugenol has elaxant and antispasmodic actions on guinea-pig isolated ileum.

Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.

N-Me-N-bis-PEG3 is a PEG-based linker for PROTACs, facilitating the joining of two essential ligands crucial for PROTAC molecule formation. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

CW-3308 is an orally active PROTAC that targets BRD9. It is composed of the PROTAC target protein ligand Naphthyridin-Me-dimethoxybenzene-COOH, the linker 3-Azaspiro[5.5]undecane-9-methanol, and the E3 ubiquitin ligase ligand Thalidomide-methylpyrrolidine. The coupling of the E3 ubiquitin ligase ligand with the linker results in the conjugate Thalidomide-pyrrolidine-C-azaspiro.

Z-1,2-Dimethoxy-4-(3-fluoro-2-propenyl)benzene is the fluorine analog of Methyl eugenol (ME), the attractant of the oriental fruit fly B. dorsalis.The E-isomer is twice as active as the Z-isomer Z-1,2-Dimethoxy-4-(3-fluoro-2-propenyl)benzene.

Palmitoylcholine is an acyl choline.1It inhibits protein kinase C activity when used at a concentration of 100 μM.2Palmitoylcholine induces hemolysis in rat erythrocytes.3Plasma levels of palmitoylcholine are decreased in female patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).1 1.Germain, A., Barupal, D.K., Levine, S.M., et al.Comprehensive circulatory metabolomics in ME/CFS reveals disrupted metabolism of acyl lipids and steroidsMetabolites10(1)34(2020) 2.Nakadate, T., and Blumberg, P.M.Modulation by palmitoylcarnitine of protein kinase C activationCancer Res.47(24 Pt 1)6537-6542(1987) 3.Cho, K.S., and Proulx, P.Interactions of acyl carnitines and other lysins with erythrocytes and reconstituted erythrocyte lipoproteinsBiochim. Biophys. Acta318(1)50-60(1973)

1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be a novel anti-breast-cancer bone me

Nε,Nε,Nε-Trimethyllysine chloride (Lys(Me)3-OH Chloride) is a methylated derivative of lysine, found in histone proteins and serves as a coenzyme in fatty acid oxidation. It is a precursor for carnitine, generated by S-adenosyl-L-methionine on lysine residues. Upon proteolysis, it is converted to 3-hydroxy-6-N-trimethyllysine by mitochondrial 6-N-trimethyllysine dioxygenase, initiating carnitine biosynthesis.

Fmoc-Ala-Thr(psi(Me,Me)pro)-OH, with catalog number T66617 and CAS number 252554-79-3, is a valuable organic compound used in life sciences research.