mal-exatecan

Mal-Exatecan, a derivative of Exatecan modified with maleimide (Mal), functions as an inhibitor of DNA topoisomerase I (topoisomeraseI).

Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan is a conjugated compound used in the synthesis of antibody-drug conjugates (ADCs), featuring a topoisomerase inhibitor derivative linked via a linker to a specific ligand unit[1].

Mal-PEG8-Val-Ala-PAB-Exatecan (Compound 9b), an antibody-drug conjugate linker (ADC linker), binds Nectin-4 polypeptides to chemotherapeutic agents for use in cancer research [1].

Mal-PEG8-Phe-Lys-PAB-Exatecan TFA is a conjugate for ADC, featuring the degradable linker Mal-PEG8-Phe-Lys-PAB combined with the cytotoxic agent Exatecan [1].

Mal-PEG2-Gly-Gly-Phe-Gly-Exatecan is a drug-linker conjugate used in antibody-drug conjugates (ADCs), consisting of Exatecan attached via a maleimidopropyl (Mal) PEGylated tetrapeptide linker, applicable in ADC synthesis and cancer research [1].

Compound 15, Mal-PEG8-Phe-Lys-PAB-Exatecan, is an antibody-drug conjugate (ADC) comprised of the degradable linker Mal-PEG8-Phe-Lys-PAB and the cytotoxic agent Exatecan [1].

Mal-cyclohexane-Gly-Gly-Phe-Gly-Exatecan is a linker molecule utilized in the synthesis of antibody-drug conjugates (ADCs), exhibiting potent antitumor activity in vitro and in vivo [1].

Gly-Mal-Gly-Gly-Phe-Gly-amide-methylcyclopropane-Exatecan is a compound used in the synthesis of Antibody-Drug Conjugates (ADCs) [1].

Mal-Gly-PAB-Exatecan-D-glucuronic acid is utilized in the synthesis of Antibody-Drug Conjugates (ADCs) and is also valuable in the research and diagnosis of tumors [1].

Compound LE14, or Mal-Val-Ala-PAB-N(SO2Me)-Exatecan, is a conjugate of the ADC toxin Exatecan and the linker Mal-Val-Ala-PAB-N(SO2Me). This compound is utilized in the synthesis of ADC FZ-AD005. FZ-AD005 is an ADC targeting delta-like ligand 3 (DLL3, KD=58.3 pM) and exhibits antitumor activity against SCLC cancer.

APL-1092 (Mal-Exo-EEVC-Exatecan) is a drug-linker conjugate utilized in the synthesis of antibody-drug conjugates (ADCs), comprising Exatecan (ADC payload) and a linker within its structure.

Val-Ala-PABC-Exatecan is a Drug-Linker Conjugate for Antibody-Drug Conjugate (ADC) synthesis, comprising a cleavable Tesirine linker (Val-Ala-PABC) and the topoisomerase I inhibitor Exatecan. It is used in the construction of ADC molecules, including Mal-PEGn-amide-va-Exatecan [1].

Val-Ala-PABC-Exatecan trifluoroacetate is a drug-linker conjugate for antibody-drug conjugates (ADC), comprising a cleavable Tesirine linker, Val-Ala-PABC, and the topoisomerase I inhibitor Exatecan. This compound facilitates the synthesis of ADC molecules, including Mal-PEGn-amide-va-Exatecan [1].