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By Target- Antibiotic
- Drug-Linker Conjugates for ADC(1)
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Results for "
mal peg4 va pbd
" in TargetMol Product Catalog.- Inhibitors & Agonists1
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- ADC/ADC Related1
Mal-PEG4-VA-PBD
T182891342820-68-1
Mal-PEG4-VA-PBD is a commonly used linker-toxin conjugate structure in antibody-drug conjugates (ADCs). It consists of Mal for conjugation to antibody thiols, PEG4 as a hydrophilic spacer arm to improve solubility, VA as a dipeptide linker cleavable by lysosomal proteases, and a pyrrolobenzodiazepine (PBD) DNA alkylator as the cytotoxic payload. Mal-PEG4-VA-PBD is cleaved by proteases upon cell entry to release PBD, which then forms covalent adducts with DNA and induces cell death.
- $905
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