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mak-683

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  • Inhibitors & Agonists
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    TargetMol | Inhibitors_Agonists
  • PROTAC Products
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    TargetMol | PROTAC
MAK-683 hydrochloride
T96812170606-94-5In house
MAK683 hydrochloride embryonic ectodermal development (EED) inhibitor, also a potent PRC2 inhibitor, blocked cancer cell proliferation (IC50=1.014nM), with IC50 values of 59, 26, and 89 nM measured in EED Alphascreen, ELISA, and LC-MS assays, respectively.
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TargetMol | Inhibitor Hot
MAK683
T152011951408-58-4In house
MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).
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MAK683-CH2CH2COOH
T137652639882-68-9
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein) and, together with a VHL ligand for the E3 ubiquitin ligase, has been used to design EED-Targeted PROTACs, specifically EED degrader-1 and PROTAC EED degrader-2 [1].
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8-10 weeks
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