lnt 1

FEN1-IN-1 (LNT-1) is an inhibitor of flap endonuclease 1 (FEN1). FEN1-IN-1 binds to the active site of FEN1. It partly achieves inhibition by the co-ordination of Mg2+ ions.

N-Acetylgalactosaminyltransferase 14 (GALNT14) is a mucin-type glycosylation enzyme polypeptide that enhances the migration of ovarian cancer by modifying Mucin 13 (MUC13). GALNT14 regulates the O-glycosylation and stability of MUC13, thereby facilitating the malignant behavior of ovarian cancer cells.

N-Acetylgalactosaminyltransferase 12 (GALNT12) is part of the UDP-N-acetylgalactosamine gene family and plays a role in the biological processes of various diseases, including tumor progression. It is a potential biomarker for fibrosarcoma, and its high expression levels are closely associated with the yes1 associated transcriptional regulator (YAP1) signaling pathway.

N-Acetylgalactosaminyltransferase 1 (GALNT1) is a glycosyltransferase that initiates mucin-type O-glycosylation by transferring α-GalNAc from UDP-GalNAc to serine (Ser) or threonine (Thr) residues in proteins. Overexpression of N-Acetylgalactosaminyltransferase 1 in gastric cancer enhances the aberrant O-glycosylation of CD44, activating the Wnt/β-catenin signaling pathway and influencing the malignant behavior of gastric cancer cells. This enzyme plays a crucial role in cancer progression and metastasis by modifying the O-glycosylation of various glycoproteins such as mucin (MUC1), osteopontin (OPN), matrix metalloproteinase-14 (MMP14), and integrin α3.

N-Acetylgalactosaminyltransferase 11 (GALNT11) is a glycosyltransferase capable of activating Notch signaling.

N-Acetylgalactosaminyltransferase 13 (GALNT13) is an enzyme involved in glycosylation. It plays a role in neuronal differentiation by glycosylating and stabilizing PDPN.