lnp lipid-2

LNP Lipid-2 is a lipid product (lipid product) used for the delivery of active molecules.

CAP2 (Cholesterol-amino-phosphate 2) hydrochloride is a lipid within the cholesterol amino phosphate (CAP) family. It is employed in the synthesis of lipid nanoparticles (LNP) for the delivery of mRNA and other efficacious payloads.

6,6′-Trehalose dioleate (6,6′-TDO) is a glycolipid extensively used for in vivo and in vitro mRNA delivery. This compound effectively encapsulates mRNA encoding hemagglutinin A (HA) from influenza A virus for use within lipid nanoparticles (LNPs), enhancing the secretion of Ifn-γ, Il-2, and Tnf-α from isolated murine spleen cells. When administered via intramuscular injection in mice, LNPs containing 6,6′-TDO predominantly accumulate in the liver and spleen. Unlike LNP formulations without 6,6′-TDO, those containing 6,6′-TDO do not reduce serum levels of blood urea nitrogen (BUN) or elevate levels of lactate dehydrogenase (LDH), troponin I, alanine aminotransferase (ALT), or aspartate aminotransferase (AST). Additionally, these LNPs enhance the serum titers of IgG1 and IgG2a antibodies in mice.

Lipid C2 is an ionizable cationic lipid utilized in the formation of lipid nanoparticles (LNP) for the delivery of mRNA in vivo. LNPs containing Lipid C2 and encapsulating mRNA reporter genes specifically accumulate in the liver and spleen of mice, while avoiding the heart, lungs, and kidneys. Additionally, LNPs with Lipid C2 that encapsulate mRNA encoding Epstein-Barr virus (EBV) protein Latent Membrane Protein 2 (LMP-2), when combined with anti-programmed cell death protein 1 (PD-1) antibodies, have been shown to reduce tumor size, reverse T cell exhaustion, increase the percentage of CD3+CD8+ central T cells and CD3+CD8+ effector memory T cells in the spleen, and decrease the percentage of CD3+T cells expressing Pd-1 in a CT26 mouse model of EBV-infected colon cancer.

TCL053, an ionizable lipid carrier, efficiently facilitates the introduction of active components, particularly nucleic acids, into cells. In combination with Dipalmitoylphosphatidylcholine (DPPC), Polyethylene glycol dimyristoyl glycerol (PEG-DMG), and cholesterol, TCL053 composes a lipid nanoparticle (LNP) system capable of delivering Cas9 mRNA and sgRNA into skeletal muscle [1] [2].

Heptadecan-9-yl 8-((6-(decyloxy)-6-oxohexyl)(2-hydroxyethyl)amino)octanoate is employed in lipid nanoparticle (LNP) delivery systems for mRNA vaccine delivery [1].

LNP Lipid-1 (Method B), a lipid compound, plays a crucial role in the formulation of lipid nanoparticles compositions and exhibits potential for transporting biologically active substances, including small molecule agents, proteins, and nucleic acids [1] [2].

CD19 car mRNA-LNP, a lipid nanoparticle (LNP) encapsulating CD19 car mRNA, is instrumental in assessing RNA delivery, translation efficacy, and cell viability among other applications. This compound is pivotal for chimeric antigen receptor T cell immunotherapy (CAR-CD19), leveraging the CD19 molecule - a critical membrane antigen expressed by B cells (i.e., leukocyte differentiation antigen) that plays a significant role in their proliferation, differentiation, activation, and antibody production, as well as enhancing BCR signal transduction [1] [2].

CD19 car circRNA-LNP, a lipid nanoparticle containing CD19 car circRNA, is designed for applications in RNA delivery, translation efficiency, and cell viability assessment. This compound is utilized in chimeric antigen receptor T cell immunotherapy (CAR-CD19), leveraging CD19 car, a chimeric antigen receptor that targets CD19. CD19, a CD molecule found on B cells (i.e., leukocyte differentiation antigen), plays a crucial role in B cell proliferation, differentiation, activation, and antibody production by facilitating BCR signal transduction [1] [2].

CL4H6, a pH-sensitive cationic lipid, serves as the primary constituent of lipid nanoparticles (LNPs). These LNPs are instrumental in targeting and delivering siRNA, leading to a potent gene-silencing response [1] [2].

Ionizable Lipid-2 (Compound 1) serves as an ionizable lipid, essential for nucleic acid delivery and the construction of lipid nanoparticles (LNPs) [1].

LNP Lipid-5 is an ionizable lipid (amino lipid) used in the formulation of lipid nanoparticles (LNP).