leukaemic

BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that suppresses TNFα-induced IκBα phosphorylation (IC50=10 μM) and also inhibits the ubiquitin-specific proteases USP7 and USP21 (IC50=0.19/0.96 μM).

Beta-mangostin (β-Mangostin) is a xanthone compound with antibacterial and antimalarial activities. Beta-mangostin present in Cratoxylum arborescens and exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. Beta-mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. Beta-mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic).

MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50 values of 30 nM and 16 nM, respectively. It exhibits greater selectivity for HDAC2/3 over other HDAC isomers and induces apoptosis in myeloid leukemic cells, indicating potential therapeutic use in leukemia and as an anti-stroke agent [1] [2].

TS-0022666 is a selective TUT4/7 inhibitor exhibiting antiproliferative and anti-leukaemic activity in vivo and in vitro. It enhances THP-1 cell sensitivity to BCL-2 inhibition, reduces uridylation, and may be used to study cancers with FOCAD deficiency.

Purinostat mesylate is a selective HDAC inhibitor. purinostat mesylate inhibits type I and type IIb HDACs (IC50: 0.81-11.5 nM). purinostat mesylate affects the cell cycle of LAMA84 and 188 BL-2 cells and induces apoptosis, showing a strong anti-leukaemic effect in vivo. purinostat mesylate has been used to study lymphocytic leukaemia. Purinostat mesylate can be used to study lymphocytic leukaemia.

Pteropodine (Standard) is a reference standard for research and analysis in studies involving Pteropodine. Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects, it also shows strong apoptotic effect on acute leukaemic lymphoblasts.

Pteropodine (Uncarine C) is a monoterpenoid indole alkaloid belonging to the class of natural products with a five-ring structure. It acts as a positive allosteric modulator of M1 muscarinic acetylcholine receptors and 5-HT2 serotonin receptors, concentration-dependently enhancing receptor signaling responses induced by agonists. Pteropodine exhibits immunomodulatory, anti-inflammatory, and neuroprotective activities and is commonly used in research on natural medicines and bioactive plant compounds.

1,4,5,6-Tetrahydroxy-7-prenylxanthone is a natural product isolated from Garcinia xanthochymus exhibiting antiproliferative activity against PC-3 cells (IC50=15.5 µM).