lenalidomide hydrochloride

Lenalidomide hydrochloride (CC-5013 hydrochloride), a Thalidomide derivative, functions as molecular glue and serves as an orally active immunomodulator. As a ligand for the ubiquitin E3 ligase cereblon (CRBN), it facilitates the selective ubiquitination and degradation of the lymphoid transcription factors IKZF1 and IKZF3 through the CRBN-CRL4 ubiquitin ligase. Specifically, Lenalidomide hydrochloride inhibits the growth of mature B-cell lymphomas, including multiple myeloma, and promotes IL-2 release from T cells [1] [2].

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride is a chemical compound comprising a cereblon (CRBN) ligand that functions as an E3 ubiquitin ligase, along with a linker. It is utilized to create the PROTAC MD-224[1].

Lenalidomide-propargyl-C2-NH2 hydrochloride is a compound that features a cereblon (CRBN) ligand for the E3 ubiquitin ligase, as well as a linker. It is utilized in the development of the PROTAC MD-224[1] system.

Desamino lenalidomide-acetylene-C-piperazine hydrochloride is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, suitable for PROTAC synthesis.

Lenalidomide 5'-piperazine-C1-piperidine hydrochloride is an E3 ligase ligand-linker conjugate that comprises a CRBN-based ligand and a linker, intended for use in synthesizing PROTACs.

Desamino lenalidomide-CH2NH2 hydrochloride is an E3 ubiquitin ligase cereblon (CRBN) ligand used for recruiting cereblon proteins. It can be linked to a target protein ligand through a linker to form PROTAC.

Desamino lenalidomide-piperazine hydrochloride is an E3 ligase ligand-linker conjugate that incorporates a CRBN-based ligand and a linker, suitable for the synthesis of PROTACs.

Desamino lenalidomide-Pip-Pip hydrochloride is an E3 ligase ligand-linker conjugate, incorporating a CRBN-based ligand and a linker, used for synthesizing PROTAC.

Desamino lenalidomide-Pip-CO-piperazine hydrochloride is an E3 ligase ligand-linker conjugate consisting of a CRBN-based ligand and a linker, which can be used for the synthesis of PROTAC.

Desamino lenalidomide-5-F-4-CH2NH2 hydrochloride is an E3 ubiquitin ligase cereblon (CRBN) ligand used for recruiting cereblon proteins. It can be coupled to a target protein ligand via a linker to form a PROTAC.

Desamino lenalidomide-Pip-azetidine hydrochloride is an E3 ligase ligand-linker conjugate that consists of a CRBN-based ligand and a linker, which is utilized in the synthesis of PROTAC.

Desamino lenalidomide-piperidine-C-piperazine hydrochloride is an E3 ligase ligand-linker conjugate that includes a CRBN-based ligand and a linker, useful for synthesizing PROTAC.

Lenalidomide-5-aminomethyl hydrochloride is a cereblon (CRBN) ligand derived from Lenalidomide. It serves as a ligand for the recruitment of the CRBN protein. When connected to the protein via a linker, Lenalidomide-5-aminomethyl hydrochloride forms a PROTAC.

Lenalidomide-4-aminomethyl hydrochloride is a compound derived from Lenalidomide, serving as a cereblon (CRBN) ligand for the recruitment of CRBN protein. By connecting Lenalidomide-4-aminomethyl hydrochloride to the ligand via a linker, PROTAC formation can be facilitated.

Lenalidomide-C4-NH2 hydrochloride is a PROTAC linker that can be used to construct small-molecule linkers or PROTAC molecules to induce the degradation or regulation of target proteins. Lenalidomide-C4-NH2 hydrochloride acts as a ligand for the E3 ubiquitin ligase CRBN and is used to study protein degradation, signaling pathway regulation, and pharmacological mechanisms.

Lenalidomide-C5-NH2 hydrochloride is a Lenalidomide-based Cereblon ligand that recruits CRBN proteins. This compound can be connected via a linker to a target protein ligand, forming PROTAC molecules, such as the PROTAC degrader for MDM2.

SJF620 hydrochloride is a PROTAC that utilizes a lenalidomide analog to recruit CRBN and ligands to target Btk, exhibiting a DC50 of 7.9 nM [1].

Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride serves as a specialized cerebellar ligand suitable for PROTAC development. It integrates an E3 ligand with a terminal piperidine, facilitating subsequent chemical reactions. This compound enables the creation of a protein degradant featuring a rigid connector [1].