kn93 phosphate

KN-93 (Phosphate) can competitively block the binding of calmodulin to the corresponding kinase. It is a calcium/calmodulin-dependent kinase II (CaMKII) inhibitor with a Ki of 370 nM. It can also inhibit the proliferation of human hepatic stellate cells.

KN-93 hydrochloride is a cell-permeable, reversible, and competitive inhibitor of calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM. KN-93 hydrochloride induces G1 cell cycle arrest in 95% of treated cells after two days, with the arrest being reversible; one day after KN-93 withdrawal, a peak of cells progresses into S and G2-M phases, providing a robust tool for cell cycle regulation studies and mechanistic investigation of CaMKII-dependent signaling.

KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.