kds-2010

SB1-F-21 is an UCHL1 inhibitor.

Tisolagiline (KDS2010) is a potent, highly selective and reversible MAO-B inhibitor with IC50=8 nM and oral activity for the treatment of Alzheimer's disease and obesity.

KDS2010 is a potent, highly selective, and reversible MAO-B inhibitor which shows 12,500-fold selectivity over MAO-A. KDS2010 overcomes the disadvantages of the irreversible MAO-B inhibitor and significantly attenuates increased astrocytic GABA levels and astrogliosis, thereby enhancing synaptic transmission, and rescuing learning and memory impairments in APP/PS1 mice.

Tisolagiline (KDS2010) methylsulfate is a selective, reversible, and orally active monoamine oxidase B (MAO-B) inhibitor with an IC50 value of 8 nM. It possesses neuroprotective and anti-neuroinflammatory properties.