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(5)
By Target- JAK
- Tyrosine Kinases(2)
- IFNAR(1)
- Interleukin(1)
- STAT(1)
- Others(2)
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- Thyroid hormone receptor(THR)
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- Adiponectin receptor
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- Amylin Receptor
- Annexin A
- Apelin receptor
- Arrestin
- Bombesin Receptor
- Bradykinin Receptor
- cAMP
- Cannabinoid Receptor
- CaSR
- CGRP Receptor
- cholecystokinin
- CRFR
- CXCR
- Dopamine Receptor
- EBI2/GPR183
- Endothelin Receptor
- GHSR
- Glucagon Receptor
- GNRH Receptor
- GPCR19
- GPR
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- GTPase
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- Leukotriene Receptor
- LPA Receptor
- LPL Receptor
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- Hydrolases,EC 3
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By Target By ResearchField- Inflammation(3)
- Cancer(2)
- Immune System(1)
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Search Result
Results for "
jak1-dependent
" in TargetMol Product Catalog.- Inhibitors & Agonists5
Oclacitinib maleate
PF-03394197 maleate, PF-03394197
T69141640292-55-2
Oclacitinib maleate (PF-03394197 maleate) is a novel inhibitor of JAK family members, with IC50 values ranging from 10 to 99 nM, and JAK1-dependent cytokines, with IC50 ranging from 36 to 249 nM, while not inhibiting a panel of 38 non-JAK kinases.
- $33
Size
QTY
Delgocitinib
JTE-052, Corectim(Delgocitinib)
T150961263774-59-9
Delgocitinib (JTE-052) is a JAK inhibitor and a specific JAK1/2/3/Tyk2 inhibitor (IC50=2.6-58 nM) that blocks multiple cytokine signaling pathways and inhibits pruritus, used for research on inflammatory and autoimmune diseases.
- $172
Size
QTY
VVD-118313
T623612875046-27-6
VVD-118313 (compound 5a), a potent, selective JAK1 inhibitor, targets an isoform-restricted allosteric cysteine to inhibit JAK1-dependent trans-phosphorylation and cytokine signaling. This compound is utilized in cancer research [1].
- $3,120
Size
QTY
Upadacitinib tartrate
ABT-494, ABT494, ABT 494
T7503L1607431-21-9
Upadacitinib is a potent and selective JAK inhibitor. Upadacitinib is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. Upadacitinib demonstrates efficacy in rat arthritis models.
- $1,970
Size
QTY
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