isoflavonoid

Colutehydroquinone is an antifungal isoflavonoid from Colutea arborescens.

Puerarin (Kakonein), also known as Kakonein, is a member of the class of compounds known as isoflavonoid C-glycosides. It is a 5-HT2C receptor antagonist.

Genistin (Genistoside) is the major isoflavonoid of soybeans and soy products.It has been reported to possess various therapeutic effects, including anti-inflammatory and anticancer activities

(-)-(S)-Equol (4',7-Dihydroxyisoflavan) is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective and estrogen receptor (ER) modulating activities. S-equol preferentially binds to and activates the beta isoform of ER in certain target tissues, while having an antagonistic effect in other tissues. This modulates the expression of ER-responsive genes in a tissue-specific manner. This agent may increase bone mineral density, affect vasomotor symptoms, and may decrease the proliferation rate of susceptible cancer cells. In addition, this agent interferes with the activity of enzymes involved in steroid biosynthesis. S-equol inhibits dihydrotestosterone (DHT) production and may inhibit the proliferation of androgen-driven prostate cancer. S-equol is the biologically active enantiomer while R-equol is essentially inactive and has a weak affinity for alpha-ER.

Dichotomitin is an natural isoflavonoid isolated from the rhizomes of Belamcanda chinensis (L.) DC.

(+)-Medicarpin, a pterocarpan, is an isoflavonoid compound derived from medicinal plant species such as Sophora japonica, Zollernia paraensis, Platymiscium yucatamun, Machaerium aristulatum, and Platymiscium floribundum. It potently inhibits osteoclastogenesis and facilitates bone healing and increased bone mass through osteoblast differentiation, mediated by the estrogen receptor (ER) β.

Osajin is an isoflavonoid natural product isolated from the fruits of Maclura pomifera. It belongs to flavonoid derivatives, and studies have reported that it exhibits multiple biological activities, including anticancer, antioxidant, and anti-inflammatory effects.

Vestitone reductase catalyzes a stereospecific NADPH-dependent reduction reaction, converting (3R)-vestitone in the biosynthesis of the antimicrobial isoflavonoid phytoalexin medicarpin.

(±)-Equol 4'-sulfate is a gut-mediated phase II metabolite of the isoflavonoid phytoestrogen (±)-equol .[1] It has been used as a standard for the quantification of unconjugated equol in rat plasma.[2]

7,2′-Dihydroxy-3′,4′-dimethoxyisoflavan 7-O-β-D-glucoside (Isomucronulatol 7-O-glucoside) is a biologically active isoflavone isolated from Astragalus membranaceus.

(±)-Equol ((R,S)-Equol) is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activity of the naturally occurring (S)-enantiomer (EC50 = 85 and 65 nM for human ERα and ERβ, respectively) is similar to that of genistein but exceeds that of daidzein. (±)-Equol preferentially binds ERβ (Ki = 0.73 nM) and demonstrates approximately 9-fold lower affinity for ERα (Ki = 6.41 nM). (±)-Equol is also a potent antagonist of dihydrotestosterone, which has important implications for prostate cancer and other androgen-mediated pathologies.

Piscerygenin (compound 4), a naturally derived isoflavonoid, can be isolated from the root bark of Piscidia erythrina [1].

Mbamiloside A (compound 4), an isoflavonoid derivative, is a natural product isolated from the stem heartwood of *Lophira alata* [1].

Puerarin (Standard) is a reference standard for research and analysis in studies involving Puerarin. Puerarin (Kakonein), also known as Kakonein, is a member of the class of compounds known as isoflavonoid C-glycosides. It is a 5-HT2C receptor antagonist.

Genistin (Standard) is a reference standard for research and analysis in studies involving Genistin. Genistin (Genistoside) is the major isoflavonoid of soybeans and soy products.It has been reported to possess various therapeutic effects, including anti-inflammatory and anticancer activities

2′-Hydroxydihydrodaidzein is an isoflavonoid phytoalexin that can be extracted from leaflets of Erythrina species inoculated with fungi. It exhibits antioxidant activity.

5,6,7,40-Tetrahydroxyisoflavone-6,7-di-O-β-D-glucopyranoside is an isoflavonoid glycoside isolated from Pueraria lobata. 5,6,7,40-Tetrahydroxyisoflavone-6,7-di-O-β-D-glucopyranoside is therefore used in phytochemical and metabolomic research systems to investigate isoflavonoid glycoside structural diversity and plant secondary metabolite profiling in Pueraria lobata biosystems.

8-Methyldisporopsin (Compound 7) is a C-methylated homo-isoflavonoid. It can be isolated from the rhizomes of Polygonatum cyrtonema.

Licoisoflavone B is an isoflavonoid from Glycyrrhiza uralensis Fisch.Licoisoflavone B inhibits lipid peroxidation and inhibits human cytochrome P450 enzymes (CYP2C8 and CYP2C9).

2'-Hydroxydaidzein is an isoflavonoid phytonutrient found in plant species, when a natural compound. 2'-Hydroxydaidzein has antioxidant activity, driven mainly by o-hydrogen bond dissociation enthalpy (BDE) and hydrogen atom transfer (HAT) mechanisms. 2'-Hydroxydaidzein inhibits chemical mediators in inflammatory cells and may be of value in the treatment and prevention of inflammatory diseases associated with excessive chemical mediator production. It may have a role in the treatment and prevention of central and peripheral inflammatory diseases associated with excessive chemical mediator production. 2'-Hydroxydaidzein inhibited the release of neutrophils and formyl-Met-Leu-Phe/cytochalasin B (fMLP/CB) in rats, with IC(50) values of 2.8+/-0.1 and 5.9+/-1.4 microM, respectively.

Pisatin is an isoflavone-type plant antitoxin derived from peas (Pisum sativum) that exhibits antifungal activity. Pisatin demonstrates significant inhibitory activity against various plant pathogenic fungi, including Fusarium oxysporum, Botrytis cinerea, and Sclerotinia sclerotiorum, with IC₅₀ values ranging from 1 to 10 μM.

Phaseollinisoflavan is an antifungal isoflavonoid, acting as a phytoalexin.

Cabreuvin is an isoflavonoid compound that can be isolated and extracted from Calopogonium mucunoides. It exhibits weak inhibitory activity against urease.