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  • IRE1
    (6)
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Results for "

ire1 rnase

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    8
    TargetMol | Inhibitors_Agonists
4μ8C
IRE1 Inhibitor III
T636314003-96-4
4μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.
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MKC8866
T155941338934-59-0
MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29 μM in human vitro). MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibit prostate cancer (PCa) tumor growth.
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D-F07
DF07, D F07
T843112361297-58-5In house
D-F07 is a novel fluorescent IRE-1 RNase inhibitor and a tricyclic chromone with potential anticancer activity.
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2-4 weeks
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TargetMol | Inhibitor Hot
GSK2850163
T114882121989-91-9In house
GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α), effectively inhibiting both its RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).
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6-8 weeks
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B I09
T148471607803-67-7In house
B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B I09 can be used to simulate the defects of XBP-1 in CLL cells., an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B I09 can be used to simulate the defects of XBP-1 in CLL cells., an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B I09 can be used to simulate the defects of XBP-1 in CLL cells.
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8-10weeks
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G-9807
G9807, G 9807
T84372 In house
G-9807 significantly increases the RNase activity of IRE1-KR-0P by stabilizing the active dimeric unit, which acts as a variable activator of RNase.
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G-1749
G1749, G 1749
T843732245057-57-0In house
G-1749 does not alter the monomer-dimer equilibrium of IRE, stimulates the RNase activity of unphosphorylated IRE1 and inhibits IRE1-3P, and significantly increases the RNase activity of IRE1-KR-0P.
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Kira8
AMG-18
T11762L1630086-20-2
Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRERNase activity with an IC50 of 5.9 nM.
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