iotox

Ioxynil is a nitrile that is benzonitrile substituted by a hydroxy group at position 4 and iodo groups at positions 3 and 5. It has a role as a xenobiotic, an environmental contaminant and a herbicide.

Argiotoxin 636 is a toxin and serves as a non-specific, non-competitive, and effective antagonist of ionotropic glutamate receptors (iGluR). It inhibits excitatory synaptic transmission in neurons and has paralyzing and muscle relaxant effects. Argiotoxin 636 can be utilized for research in neurological disorders.

Pumiliotoxins (PTXs), are one of several toxins found in the skin of poison dart frogs. There are three different types of this toxin: A, B and C, of which toxins A and B are more toxic than C. Pumiliotoxins interfere with muscle contraction by affecting

Gliotoxin-13C13is intended for use as an internal standard for the quantification of gliotoxin by GC- or LC-MS. Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains ofAspergillusand other fungi with diverse biological activities.1,2,3,4,5,6,7,8It inhibits 20S proteasomal chymotrypsin activity (IC50= 10 μM), blocking the degradation of IκBα and preventing the activation of NF-κB.2,3Gliotoxin induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutrophils.4,5It suppresses viral infection by Nipah and Hendra virus in HEK293T cells (IC50s = 149 and 579 nM, respectively).6Under reducing conditions, gliotoxin inhibits leukotriene A4hydrolase epoxide hydrolase activity, but not aminopeptidase activity, and leukotriene B4synthesis in neutrophils and monocytes.7

Kaliotoxin is an inhibitor of neuronal BK-type peptide groups and specifically inhibits Kv channels and calcium-activated potassium channels. Kaliotoxin has research significance on the regulation of cell membrane potential and neuronal excitability. The product number is T37808 and the CAS number is 145199-73-1

Gliotoxin monoacetate is a toxin found in Aspergillus. It induces apoptosis in cervical cancer cells and chondrosarcoma cells, suppresses the adaptive immune response in leukocytes, and inhibits the proteasome in Plasmodium falciparum.

Kaliotoxin (1-37), a toxin derived from the scorpion Androctonus mauretanicus mauretanicus, acts as a potent blocker of calcium-dependent potassium channels [1].

Iberiotoxin (TFA) is a selective inhibitor of high conductance Ca2+-activated K+ channels, with a dissociation constant (Kd) of approximately 1 nM, and does not inhibit other types of voltage-dependent ion channels [1] [2] [3].

Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway.

Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist.

Cardiotoxin Analog IV (6-12) TFA, a partial peptide of Cardiotoxin Analog IV, is derived from the venom of the Taiwan Cobra, showcasing the unique properties of snake venom cardiotoxin[1].

Cardiotoxin Analog (CTX) IV (6-12) is a peptide fragment of Cardiotoxin Analog (CTX) IV, isolated from the venom of the Taiwan Cobra (Naja atra).

Selective blocker of the big conductance Ca2+-activated K+ channel.