inositol

D-myo-Inositol-1,4,5,6-tetraphosphate tetrasodium (Inositol 1,4,5,6-tetraphosphate tetrasodium) is one of the isomers of inositol oligophosphates. At concentrations of 8-10 μM, it almost completely inhibits calcium-activated chloride channels (chloride channels).

Neo-Inositol is a group of chemically very stable small polar molecules with a variety of properties. It is one of the naturally occurring but rare inositol stereoisomers.

D-myo-Inositol-1,4,5-triphosphate tripotassium (Ins(1,4,5)-P3 tripotassium) is a second messenger in cellular signal transduction that triggers Ca2+ mobilization.

D-myo-Inositol-4-phosphate (Ins(4)P1) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-diphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(4)P1 can be formed by dephosphorylation of Ins(1,4)P2 by inositol polyphosphate 1-phosphatase or dephosphorylated to inositol by inositol monophosphatase.

D-myo-Inositol-1,4,5,6-tetraphosphate (D-Ins(1,4,5,6)P4) is an isomer of inositol polyphosphate. At concentrations of 8-10 μM, it almost entirely inhibits calcium-activated chloride channels.

Trimethylsilyl-meso-inositol is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

i-Inositol (myo-Inositol) is an intracellular phosphate compound involved in cell signaling and may stimulate tumor cell differentiation.

Inositol nicotinate (Mesotal) has the effect of lowering cholesterol and expanding peripheral blood vessels for hypercholesterolemia and atherosclerosis.

D-myo-Inositol-1,4,5-triphosphate trisodium (Inositol 1,4,5-trisphosphate trisodium) is a second messenger produced in cells by the phospholipase C-mediated hydrolysis of phosphatidylinositol-4,5-bisphosphate. It binds to Ins(1,4,5)P3 receptors, resulting in the opening of calcium channels and an increase in intracellular calcium.

D-chiro-Inositol (D-(+)-CHIRO-INOSITOL) is an epimer of myo-inositol that is found in certain mammalian glycosylphosphatidylinositol protein anchors and inositol phosphoglycans possessing insulin-like bioactivity.

Scyllo-Inositol (Scyllitol) is one of the inositol stereoisomers, rare in the nature, and expected as a promising disease-modifying therapeutic agent for Alzheimer's disease.

i-Inositol (Standard) is the standard substance of i-Inositol for quantitative analysis and quality control. i-Inositol is an essential nutrient involved in cell signaling and lipid metabolism.

Myo-Inositol-D6 (Standard) is a reference standard of Myo-Inositol-D6 intended for quantitative analysis, quality control, and related biochemical research applications. myo-Inositol-d6 is a deuterated compound of myo-Inositol. myo-Inositol has a CAS number of 87-89-8. Inositol is a intracellular phosphate compound, involved in cell signaling and may stimulate tumor cell differentiation.

PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of active ERK1.

Phytic acid (Fytic Acid) is a complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent.

Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+/K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity.

m-3M3FBS is a phospholipase C (PLC) activator.

GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α), effectively inhibiting both its RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).

Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFRβ (IC50: 80/2 nM), and c-kit.

Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that inhibits VEGFR2 and PDGFRβ (IC50=80/2 nM). It exhibits antitumor activity and is used for treating kidney cancer and gastrointestinal tumors.

Phytic acid dodecasodium salt hydrate (myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate) is a phosphorus storage compound of seeds and cereal grains. Phytic acid dodecasodium salt hydrate inhibits the enzymatic superoxide source xanthine oxidase with an IC50 of 6 mM and has antioxidative, neuroprotective, and anti-inflammatory effects.

D-Pinitol (Methylinositol) has anti-inflammatory activity. D-Pinitol(Methylinositol) exerts insulin-like activity, used for many diabetic associated conditions. D-Pinitol(Methylinositol) is a safe nutrient to reduce calorie consumption when supplementing with creatine.

Phytic acid dipotassium salt is an endogenous metabolite that inhibits β-secretase 1 (BACE1).

Phytic acid sodium salt (Sodium phytate hydrate) is known to function as a [PO4]3- storage depot and a precursor for other inositol phosphates and pyrophosphates. It is a potent chelator of divalent and trivalent cations in vitro.