idr-1

IDR-1 is an antimicrobial peptide active against both Gram-positive and Gram-negative bacteria. This compound modulates innate immunity to counter infections while avoiding evident toxicities. Additionally, IDR-1 exhibits anti-inflammatory and anti-infective properties, increases the levels of monocyte chemokines, and reduces the release of pro-inflammatory cytokines.

IDR-1018 acetate is an innate defense regulator conjugate with a minimum inhibitory concentration (MIC) of 16 μg/mL against MRSA USA300 LAC, MRSA SAP 0017, and S. epidermidis ATCC14990. It serves a role in the synthesis of V-IDR1018 (vancomycin-innate defense regulator conjugate).

IDR-HH2 is an immunoregulatory peptide with the ability to modulate the host cytokine chemokine environment. It enhances the adhesion of monocytes and THP-1 cells to fibronectin. Additionally, IDR-HH2 exhibits antibacterial activity, inhibiting P. aeruginosa and S. aureus with MIC values of 75 µg mL and 38 µg mL, respectively.