idr 1

IDR-1 is an antimicrobial peptide active against both Gram-positive and Gram-negative bacteria. This compound modulates innate immunity to counter infections while avoiding evident toxicities. Additionally, IDR-1 exhibits anti-inflammatory and anti-infective properties, increases the levels of monocyte chemokines, and reduces the release of pro-inflammatory cytokines.

IDR 1002, an innate defense regulator peptide, effectively diminishes bacterial load and mitigates inflammatory responses in murine models of sinusitis and acute bacterial lung infections. It suppresses LPS-induced activation of NF-κB and COX-2 while promoting the phosphorylation and activation of p38, ERK1/2, MSK1, and CREB.

Dusquetide (SGX942) TFA, a first-in-class innate defense regulator (IDR), modulates the innate immune response to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) by interacting with p62. This compound is effective in both diminishing inflammation and enhancing the elimination of bacterial infections [1].

IDR-HH2 is an immunoregulatory peptide with the ability to modulate the host cytokine/chemokine environment. It enhances the adhesion of monocytes and THP-1 cells to fibronectin. Additionally, IDR-HH2 exhibits antibacterial activity, inhibiting P. aeruginosa and S. aureus with MIC values of 75 µg/mL and 38 µg/mL, respectively.