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Results for "
ido/tdo in 1
" in TargetMol Product Catalog- Inhibitors & Agonists3
IDO/TDO-IN-1
T116232033173-01-0
IDO TDO-IN-1 is an orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50s: 9.7 and 47 nM).
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(R)-IDO/TDO-IN-1
T847282033173-00-9
(R)-IDO/TDO-IN-1 (compound 25), an indoleamine-2,3-dioxygenase (IDO) inhibitor, demonstrates good pharmacokinetic properties and exerts anti-tumor effects in the MC38 xenograft model. This compound exhibits synergy when combined with the anti-PD-1 monoclonal antibody (SHR-1210) [1].
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IDO/Tubulin-IN-2
T745362409479-24-7
IDO Tubulin-IN-2 (HT2) is a potent inhibitor of TDO and tubulin, showing significant efficacy against cancer cell lines U87, HepG2, A549, HCT-116, and LO2, with respective IC50 values of 0.43, 0.036, 0.041, 0.095, and 1.04 μM. Additionally, IDO Tubulin-IN-2 markedly enhances antitumor activity [1].
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