hydratase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11337	Fumarate hydratase-IN-1		Others
	Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM. Fumarate hydratase-IN-1 is a cell-permeable fumarate hydratase inhibitor.		Others
T11336	Fumarate hydratase-IN-2 sodium salt		Others
	Fumarate hydratase-IN-2 sodium salt (compound 3) is a cell-permeable and competitive fumarate hydratase inhibitor ( K i =4.5 μM). Fumarate hydratase-IN-2 sodium salt has nutrient-dependent cytotoxicity [1].		Others
T6759	AP-III-a4	ENOblock	Glucokinase
	AP-III-a4 (ENOblock) (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 μM.		Glucokinase
T71901	MP-1
	MP-1 is a covalent inhibitor of fumarate hydratase (FH) that exhibits cytotoxicity dependent on FH. MP-1 engages a functional cysteine in the Zn-finger domain of the tRNA methyltransferase enzyme TRMT1.

Compounds

Fumarate hydratase-IN-1

T11337

Synonym:

Target: Others

Fumarate hydratase-IN-2 sodium salt

Cat No.	Product Name	Synonyms	Targets
T5564	Tricarballylic acid	β-Carboxyglutaric acid,1,2,3-Propanetricarboxylic acid,Carballylic acid,Propane-1,2,3-tricarboxylic acid	aconitase , Mitochondrial Metabolism
	Tricarballylic acid (Carballylic acid) is an inhibitor of aconitase.		aconitase , Mitochondrial Metabolism
T4766	3-Methylglutaric acid		Endogenous Metabolite
	Methylglutaric acid is a leucine metabolite. A large amount of methylglutaric acid is identified in urine of patients with deficiency of 3-methylglutaconyl coenzyme A hydratase (PMID 6181239 ). Methylglutaric acid is als...		Endogenous Metabolite
T78467	Trans-10-Heptadecenoic acid
	Trans-10-heptadecenoic acid, a trans-fatty acid, undergoes polymerization to form polyhydroxy-chain alkanoates via the enzymatic actions of 2,4-dienyl-CoA reductase and Delta3, Delta2-enyl-CoA isomerase. In the enzyme's ...

Natural Products

Tricarballylic acid

T5564

Synonym: β-Carboxyglutaric acid,1,2,3-Propanetricarboxylic acid,Carballylic acid,Propane-1,2,3-tricarboxylic acid

Target: aconitase, Mitochondrial Metabolism

3-Methylglutaric acid

T4766

Synonym:

Target: Endogenous Metabolite

trans-10-Heptadecenoic acid

T78467

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02003	FH/Fumarate Hydratase Protein, Human, Recombinant (His)	Human	E. coli
	Fumarate Hydratase (FH) is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extende...
TMPJ-00313	Fumarase Protein, Human, Recombinant	Human	E. coli
	Fumarase is an enzyme that catalyze the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid or Krebs cycle. Fumarase exists in both form, cytosolic formand N-terminal extend...
TMPY-03464	ECH1 Protein, Human, Recombinant (His)	Human	E. coli
	ECH1 is a member of the hydratase/isomerase superfamily. ECH1 shows high sequence similarity to enoyl-CoA hydratases of several species, particularly within a conserved domain characteristic of these proteins. ECH1 con...
TMPH-02642	ECHS1 Protein, Mouse, Recombinant (C225S, HA & His)	Mouse	Baculovirus
	Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcr...
TMPH-03759	ECHS1 Protein, Mouse, Recombinant (HA & His)	Mouse	E. coli
	Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcr...
TMPH-03259	Carbonic Anhydrase 2 Protein, Rat, Recombinant (His)	Rat	E. coli
	Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide abso...
TMPH-03258	Carbonic Anhydrase 1 Protein, Rat, Recombinant (His & SUMO)	Rat	E. coli
	Reversible hydration of carbon dioxide.
TMPH-03468	D-serine dehydratase Protein, Salmonella heidelberg, Recombinant (His & SUMO)	Salmonella heidelberg	E. coli

TMPH-02950	HADHB Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and...
TMPH-02245	HADHB Protein, Human, Recombinant (GST)	Human	E. coli
	Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and...
TMPY-02375	AcnB Protein, E. coli, Recombinant	E. coli	E. coli
	Escherichia coli contains two major aconitases (Acns), AcnA and AcnB. They are distantly related monomeric Fe-S proteins that contain different arrangements of four structural domains. acnA is specifically subject to Sox...
TMPH-02949	HADHA Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and...