hydratase

Tricarballylic acid (Carballylic acid) is an inhibitor of aconitase.

Methylglutaric acid is a leucine metabolite. A large amount of methylglutaric acid is identified in urine of patients with deficiency of 3-methylglutaconyl coenzyme A hydratase (PMID 6181239 ). Methylglutaric acid is also found to be associated with 3-hyd

Isocitric acid (Isocitrate), an isomer of citric acid, is a substrate for citric acid cycle and an endogenous metabolite, which has potential for the treatment of Parkinson’s disease, Fe-deficiency anemia, and metabolic myopathies associated with a shortage of succinate dehydrogenase and aconitate hydratase, as well as the mutation of the gene of NADP-dependent isocitrate dehydrogenase 1 (IDH1).

Trans-10-heptadecenoic acid, a trans-fatty acid, undergoes polymerization to form polyhydroxy-chain alkanoates via the enzymatic actions of 2,4-dienyl-CoA reductase and Delta3, Delta2-enyl-CoA isomerase. In the enzyme's absence, degradation is facilitated by enyl-CoA hydratase II from the multifunctional enzyme (MFE), causing significant intracellular carbon release through both reductase-dependent and direct MFE-dependent pathways [1].