human gpr39 without zn2+

TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s of 180 nM and 5 nM, respectively.

Taurolithocholic Acid 3-sulfate sodium salt is a GPR39 agonist. In the absence of Zn²⁺, its EC50 values are 71.6 μM and 69.4 μM in M39-20 and hGPR39-2 cells, respectively; in the presence of Zn²⁺, the values are 9 μM and 9.6 μM, respectively. Taurolithocholic Acid 3-sulfate sodium salt activates the GPR39 receptor and mediates intracellular calcium signaling pathways independently of the Zn²⁺-binding sites H17 and H19, and can be used in research on gallbladder-related diseases.