hspc-187

Serine threonine-protein kinase D2, also known as PRKD2 and PKD2, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser Thr protein kinase family and PKD subfamily. PRKD2 PKD2 is widely expressed. It contains one PH domain, two phorbol-ester DAG-type zinc fingers and one protein kinase domain. PRKD2 PKD2 is activated by DAG and phorbol esters. Phorbol-ester DAG-type domains bind DAG, mediating translocation to membranes. Autophosphorylation of Ser-71 and phosphorylation of Ser-76 by PKC relieves auto-inhibition by the PH domain. PRKD2 PKD2 converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress.