hsf1 activator

Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indica

HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis (HSF1).

Tonantzitlolone is a natural agonist of tprc1/4/5 channels, also acting as a dual pkcα and pkcθ activator, inducing an insulin resistant phenotype by inhibiting irs1 and the pi3k/akt pathway, activating the heat shock factor 1 (hsf1) transcription factor driving glucose dependency