hsert

Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Maleate is the maleate salt form of trimipramine, a tricyclic secondary amine of the dibenzazepine class, with an antidepressant property.

Desvenlafaxine (O-Desmethylvenlafaxine) is a cyclohexanol and phenol derivative and metabolite of venlafaxine that functions as a serotonin and noradrenaline reuptake inhibitor (SNRI) and is used as an antidepressive agent.

Desvenlafaxine succinate hydrate (WY 45233 Succinate) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI).

STOCK3S-30866 is a selective allosteric inhibitor targeting the human serotonin transporter (hSERT).

Trimipramine N-oxide, an active metabolite of the tricyclic antidepressant trimipramine, effectively inhibits human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT), and the human organic cation transporters (hOCT1 and hOCT2), with IC50 values of 11.7, 3.59, 9.4, 9.35, and 27.4 nM, respectively. It is utilized in the research of depression and anxiety [1].

AC-4-248 is an atypical, noncompetitive inhibitor of the dopamine transporter (DAT) that can reduce the inhibitory potency of cocaine on DAT. Additionally, it is a non-selective inhibitor of SLC6 transporters, with IC50 values of 45.5 μM for hDAT, 96.2 μM for hSERT, and 250 μM for hNET.